Tchem NOX4 NADPH oxidase 4

Protein Summary

Description

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1. This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• Q9NPH5
• A8K715
• B7Z520
• E7EMD7
• Q5K3R4
• Q5K3R5
• Q5K3R6
• Q5K3R8
• Q7Z7G3
• Q86V92

Gene Name

• NOX4

Ensembl ID

• ENST00000263317
• ENSP00000263317
• ENSG00000086991
• ENST00000343727
• ENSP00000344747
• ENST00000375979
• ENSP00000365146
• ENST00000393282
• ENSP00000376961
• ENST00000424319
• ENSP00000412446
• ENST00000527956
• ENSP00000433797
• ENST00000529343
• ENSP00000435474
• ENST00000531342
• ENSP00000435039
• ENST00000532825
• ENSP00000434924
• ENST00000534731
• ENSP00000436892

Symbol

• RENOX
• KOX
• KOX-1
• RENOX

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
cellular component	0.93
protein domain	0.85
molecular function	0.81
disease	0.78

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Nadph Oxidase 4

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Nadph Oxidase 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1439.65   (req: < 5)

Gene RIFs: 353   (req: <= 3)

Antibodies: 574   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1439.65   (req: >= 5)

Gene RIFs: 353   (req: > 3)

Antibodies: 574   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 83

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1