Tclin IL1RAP Interleukin-1 receptor accessory protein

Protein Summary

Description

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity). Isoform 4: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity). This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018]

Uniprot Accession IDs

• Q9NPH3
• B1NLD0
• D3DNW0
• O14915
• Q86WJ7
• IL-1 receptor accessory protein

Gene Name

• IL1RAP

Ensembl ID

• ENST00000072516
• ENSP00000072516
• ENSG00000196083
• ENST00000317757
• ENSP00000314807
• ENST00000342550
• ENSP00000345829
• ENST00000412504
• ENSP00000412053
• ENST00000413869
• ENSP00000416296
• ENST00000422485
• ENSP00000409352
• ENST00000422940
• ENSP00000387371
• ENST00000439062
• ENSP00000401132
• ENST00000443369
• ENSP00000408893
• ENST00000447382
• ENSP00000390541

Symbol

• C3orf13
• IL1R3
• IL1R3
• C3orf13
• IL-1RAcP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
trait	0.93
transcription factor perturbation	0.88
protein domain	0.85
gene perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-1 Receptor Accessory Protein

DTO Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-1 Receptor Accessory Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.11   (req: < 5)

Gene RIFs: 51   (req: <= 3)

Antibodies: 363   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.11   (req: >= 5)

Gene RIFs: 51   (req: > 3)

Antibodies: 363   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1