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Tclin
IL1RAP
Interleukin-1 receptor accessory protein

Protein Summary
Description
Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production fr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000072516
  • ENSP00000072516
  • ENSG00000196083
  • ENST00000317757
  • ENSP00000314807
  • ENST00000342550
  • ENSP00000345829
  • ENST00000412504
  • ENSP00000412053
  • ENST00000413869
  • ENSP00000416296
  • ENST00000422485
  • ENSP00000409352
  • ENST00000422940
  • ENSP00000387371
  • ENST00000439062
  • ENSP00000401132
  • ENST00000443369
  • ENSP00000408893
  • ENST00000447382
  • ENSP00000390541

Symbol
  • C3orf13
  • IL1R3
  • IL1R3
  • C3orf13
  • IL-1RAcP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
trait
0.93
transcription factor perturbation
0.88
protein domain
0.85
gene perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.46   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 363   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.46   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 363   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
anakinra
no chemical structure image available
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
63.7
amyloid plaque accumulation rate
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
63.7
amyloid plaque accumulation rate
1
35
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor accessory protein
VGNC:1847
460935
Macaque
interleukin 1 receptor accessory protein
574387
Mouse
MGI:104975
16180
Rat
RGD:2893
25466
Dog
interleukin 1 receptor accessory protein
VGNC:41960
488126
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor accessory protein
Macaque
interleukin 1 receptor accessory protein
Mouse
Rat
Dog
interleukin 1 receptor accessory protein
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NPH3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (117)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-1 signaling
Reactome
Interleukin-33 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-1 signaling
Interleukin-33 signaling
Gene Ontology Terms (25)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (62)
1 – 10 of 62
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.998589128
p_ni:  0.000287548
p_wrong:  0.001123324
Score:  0.23
Data Source:  BioPlex,STRINGDB
PCDHA12
Tdark
Novelty:  0.71618264
p_int:  0.985442291
p_ni:  0.014294126
p_wrong:  0.000263583
Score:  0.189
Data Source:  BioPlex,STRINGDB
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.985442291
p_ni:  0.014294126
p_wrong:  0.000263583
Score:  0.179
Data Source:  BioPlex,STRINGDB
IL1B
Tclin
Novelty:  0.0000308
Score:  0.997
Data Source:  Reactome,STRINGDB
IL1R1
Tclin
Novelty:  0.0014281
Score:  0.991
Data Source:  Reactome,STRINGDB
IRAK1
Tchem
Family:  Kinase
Novelty:  0.00170873
Score:  0.975
Data Source:  Reactome,STRINGDB
MYD88
Tbio
Novelty:  0.00037931
Score:  0.972
Data Source:  Reactome,STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.968
Data Source:  Reactome,STRINGDB
TOLLIP
Tbio
Novelty:  0.01032371
Score:  0.965
Data Source:  Reactome,STRINGDB
IL1A
Tchem
Novelty:  0.00019366
Score:  0.963
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  68.46

PubMed score by year
PubTator Score  69.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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