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Tbio
ISYNA1
Inositol-3-phosphate synthase 1

Protein Summary
Description
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds. This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338128
  • ENSP00000337746
  • ENSG00000105655
  • ENST00000457269
  • ENSP00000415458
  • ENST00000578963
  • ENSP00000475677

Symbol
  • INO1
  • IPS
  • INO1
  • INOS
  • IPS 1
  • IPS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
transcription factor perturbation
0.8
kinase perturbation
0.71
histone modification site profile
0.62
cell type or tissue
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.53   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.53   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
46.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
inositol-3-phosphate synthase 1
719487
Mouse
MGI:1919030
71780
Rat
RGD:1359423
290651
Dog
inositol-3-phosphate synthase 1
VGNC:42116
476667
Horse
inositol-3-phosphate synthase 1
VGNC:19156
100069557
Species
Name
OMA
EggNOG
Inparanoid
Macaque
inositol-3-phosphate synthase 1
Mouse
Rat
Dog
inositol-3-phosphate synthase 1
Horse
inositol-3-phosphate synthase 1
Pathways (8)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP2, IP, and Ins in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP2, IP, and Ins in the cytosol
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CACAO
Protein-Protein Interactions (91)
1 – 10 of 91
NAA30
Tbio
Family: Enzyme
Novelty: 0.04701961
p_int: 0.961948224
p_ni: 0.038051776
Data Source: BioPlex
IMPA1
Tclin
Family: Enzyme
Novelty: 0.00766053
Score: 0.975
Data Source: STRINGDB
IMPA2
Tbio
Family: Enzyme
Novelty: 0.03983031
Score: 0.966
Data Source: STRINGDB
IMPAD1
Tbio
Family: Enzyme
Novelty: 0.08211251
Score: 0.916
Data Source: STRINGDB
INPP4A
Tbio
Family: Enzyme
Novelty: 0.03714963
Score: 0.905
Data Source: STRINGDB
INPP4B
Tbio
Family: Enzyme
Novelty: 0.02053228
Score: 0.9
Data Source: STRINGDB
PGD
Tchem
Family: Enzyme
Novelty: 0.00576529
Score: 0.832
Data Source: STRINGDB
MIOX
Tbio
Family: Enzyme
Novelty: 0.00962281
Score: 0.827
Data Source: STRINGDB
CDIPT
Tbio
Family: Enzyme
Novelty: 0.00560887
Score: 0.817
Data Source: STRINGDB
PLS1
Tbio
Novelty: 0.00538817
Score: 0.816
Data Source: STRINGDB
Publication Statistics
PubMed Score  346.53

PubMed score by year
PubTator Score  218.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer