ISYNA1
Inositol-3-phosphate synthase 1
Protein Summary
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds. This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
- ENST00000338128
- ENSP00000337746
- ENSG00000105655
- ENST00000457269
- ENSP00000415458
- ENST00000578963
- ENSP00000475677
- INO1
- IPS
- INO1
- INOS
- IPS 1
- IPS-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.86 | ||
transcription factor perturbation | 0.8 | ||
kinase perturbation | 0.71 | ||
histone modification site profile | 0.62 | ||
cell type or tissue | 0.61 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 346.53 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 86 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 346.53 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 86 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 1 | 1 | 1 | 46.9 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 1 | 46.9 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | inositol-3-phosphate synthase 1 | 719487 | ||||||
Mouse | MGI:1919030 | 71780 | ||||||
Rat | RGD:1359423 | 290651 | ||||||
Dog | inositol-3-phosphate synthase 1 | VGNC:42116 | 476667 | |||||
Horse | inositol-3-phosphate synthase 1 | VGNC:19156 | 100069557 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | inositol-3-phosphate synthase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | inositol-3-phosphate synthase 1 | |||||
Horse | inositol-3-phosphate synthase 1 | |||||
Pathways (8)
Reactome (3)
KEGG (2)
PathwayCommons (2)
UniProt (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Inositol phosphate metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Synthesis of IP2, IP, and Ins in the cytosol | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Inositol phosphate metabolism | ||||
Metabolism | ||||
Synthesis of IP2, IP, and Ins in the cytosol | ||||
Gene Ontology Terms (6)
Functions (1)
Components (2)
Processes (3)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | CACAO | |||
Protein-Protein Interactions (91)
1 – 10 of 91
NAA30
Family: Enzyme
Novelty: 0.04701961
p_int: 0.961948224
p_ni: 0.038051776
Data Source: BioPlex
IMPA1
Family: Enzyme
Novelty: 0.00766053
Score: 0.975
Data Source: STRINGDB
IMPA2
Family: Enzyme
Novelty: 0.03983031
Score: 0.966
Data Source: STRINGDB
IMPAD1
Family: Enzyme
Novelty: 0.08211251
Score: 0.916
Data Source: STRINGDB
INPP4A
Family: Enzyme
Novelty: 0.03714963
Score: 0.905
Data Source: STRINGDB
INPP4B
Family: Enzyme
Novelty: 0.02053228
Score: 0.9
Data Source: STRINGDB
PGD
Family: Enzyme
Novelty: 0.00576529
Score: 0.832
Data Source: STRINGDB
MIOX
Family: Enzyme
Novelty: 0.00962281
Score: 0.827
Data Source: STRINGDB
CDIPT
Family: Enzyme
Novelty: 0.00560887
Score: 0.817
Data Source: STRINGDB
PLS1
Novelty: 0.00538817
Score: 0.816
Data Source: STRINGDB
Publication Statistics
PubMed Score 346.53
PubMed score by year
PubTator Score 218.79
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: