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Tbio
ACP6
Lysophosphatidic acid phosphatase type 6

Protein Summary
Description
Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000487562
  • ENSP00000481777
  • ENSG00000162836
  • ENST00000583509
  • ENSP00000463574

Symbol
  • ACPL1
  • LPAP
  • LPAP
  • ACPL1
  • PACPL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
histone modification site profile
0.8
transcription factor binding site profile
0.77
PubMedID
0.75
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.49   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.49   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.83387117
p_ni:  0.000002172
p_wrong:  0.166126658
Data Source:  BioPlex
GPR89A
Tbio
Family:  IC
Novelty:  0.06782776
Score:  0.731
Data Source:  STRINGDB
GPR89B
Tbio
Family:  IC
Novelty:  0.06782776
Score:  0.731
Data Source:  STRINGDB
CHD1L
Tbio
Family:  Enzyme
Novelty:  0.00980287
Score:  0.7
Data Source:  STRINGDB
CNKSR2
Tbio
Family:  Enzyme
Novelty:  0.05451075
Score:  0.686
Data Source:  STRINGDB
ANXA9
Tbio
Novelty:  0.01570358
Score:  0.681
Data Source:  STRINGDB
PRKAB2
Tchem
Family:  Enzyme
Novelty:  0.02815065
Score:  0.676
Data Source:  STRINGDB
SLC27A3
Tbio
Family:  Transporter
Novelty:  0.1037612
Score:  0.674
Data Source:  STRINGDB
NBPF11
Tdark
Novelty:  0.85421227
Score:  0.669
Data Source:  STRINGDB
FMO5
Tbio
Family:  Enzyme
Novelty:  0.05610368
Score:  0.642
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
78.6
leukocyte count
1
1
1
78.3
granulocyte count
1
1
1
47.7
1
1
0
1
44.2
body height
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
78.6
leukocyte count
1
78.3
granulocyte count
1
47.7
0
1
44.2
body height
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acid phosphatase 6, lysophosphatidic
VGNC:24
457249
Macaque
acid phosphatase 6, lysophosphatidic
710431
Mouse
MGI:1931010
66659
Rat
RGD:1306336
295305
Dog
acid phosphatase 6, lysophosphatidic
475822
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acid phosphatase 6, lysophosphatidic
Macaque
acid phosphatase 6, lysophosphatidic
Mouse
Rat
Dog
acid phosphatase 6, lysophosphatidic
Publication Statistics
PubMed Score 18.49
PubMed score by year
PubTator Score 8.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title