Protein Summary
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]
- ENST00000262376
- ENSP00000262376
- ENSG00000118900
- ENST00000396658
- ENSP00000379894
- ENST00000590769
- ENSP00000468740
- VT
- VT4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.97 | ||
ligand (protein) perturbation | 0.83 | ||
transcription factor | 0.8 | ||
histone modification site profile | 0.77 | ||
tissue sample | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.39 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 122 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.39 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 122 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (60)
ASF1B
Novelty: 0.05716701
p_int: 0.999999989
p_ni: 3e-9
p_wrong: 8e-9
Score: 0.483
Data Source: BioPlex,STRINGDB
ASF1A
Novelty: 0.02544466
p_int: 0.999999969
p_ni: 1.5e-8
p_wrong: 1.7e-8
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | DNA Damage/Telomere Stress Induced Senescence | ||||
Reactome | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
DNA Damage/Telomere Stress Induced Senescence | ||||
Formation of Senescence-Associated Heterochromatin Foci (SAHF) | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 3 | 4 | 96.6 | |||||
body mass index | 2 | 2 | 2 | 72.8 | |||||
waist-hip ratio | 2 | 2 | 2 | 49.2 | |||||
BMI-adjusted waist circumference | 1 | 2 | 2 | 42.2 | |||||
diastolic blood pressure | 1 | 1 | 1 | 40.7 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 4 | 96.6 | |||||
body mass index | 2 | 72.8 | |||||
waist-hip ratio | 2 | 49.2 | |||||
BMI-adjusted waist circumference | 2 | 42.2 | |||||
diastolic blood pressure | 1 | 40.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ubinuclein 1 | VGNC:5950 | 453892 | |||||
Macaque | ubinuclein 1 | 706838 | ||||||
Mouse | MGI:1891307 | 170644 | ||||||
Rat | RGD:1311582 | 302935 | ||||||
Dog | ubinuclein 1 | VGNC:48081 | 490022 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ubinuclein 1 | |||||
Macaque | ubinuclein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ubinuclein 1 | |||||
Publication Statistics
PubMed Score 49.39
PubMed score by year
PubTator Score 14.29
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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