Tbio UBN1 Ubinuclein-1

Protein Summary

Description

Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q9NPG3
• B7Z6D3
• D3DUE8
• Q13079
• Q9P1P7

Gene Name

• UBN1

Ensembl ID

• ENST00000262376
• ENSP00000262376
• ENSG00000118900
• ENST00000396658
• ENSP00000379894
• ENST00000590769
• ENSP00000468740

Symbol

• VT
• VT4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
ligand (protein) perturbation	0.83
transcription factor	0.8
histone modification site profile	0.77
tissue sample	0.7

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.18   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 122   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.18   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	1	1	1		80.4
waist-hip ratio	EFO_0004343	1	1	1		59.1
sex hormone-binding globulin measurement	EFO_0004696	1	1	1		45
mean platelet volume	EFO_0004584	1	1	1		29.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	1		80.4
waist-hip ratio	EFO_0004343	1		59.1
sex hormone-binding globulin measurement	EFO_0004696	1		45
mean platelet volume	EFO_0004584	1		29.6

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Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ubinuclein 1	VGNC:5950	453892
Macaque	ubinuclein 1		706838
Mouse	ubinuclein 1	MGI:1891307	170644
Rat	ubinuclein 1	RGD:1311582	302935
Dog	ubinuclein 1	VGNC:48081	490022

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ubinuclein 1
Macaque	ubinuclein 1
Mouse	ubinuclein 1
Rat	ubinuclein 1
Dog	ubinuclein 1

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NPG3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (5)

Reactome (5)

Cellular Senescence (R-HSA-2559583)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular Senescence	164 targets	R-HSA-2559583
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	DNA Damage/Telomere Stress Induced Senescence	61 targets	R-HSA-2559586
Reactome	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	17 targets	R-HSA-2559584

Name	Explore in Pharos	Explore in Source
Cellular Senescence	164 targets	R-HSA-2559583
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
DNA Damage/Telomere Stress Induced Senescence	61 targets	R-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	17 targets	R-HSA-2559584

Gene Ontology Terms (10)

Functions (2)

Components (5)

Processes (3)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity	Traceable Author Statement (TAS)	ProtInc
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (60)

Explore Interacting Targets

1 – 10 of 60

• See Interactions on String-DB

ASF1B

Tbio

Novelty: 0.05716701

p_int: 0.999999989

p_ni: 3e-9

p_wrong: 8e-9

Score: 0.483

Data Source: BioPlex,STRINGDB

ASF1A

Tchem

Novelty: 0.02544466

p_int: 0.999999969

p_ni: 1.5e-8

p_wrong: 1.7e-8

Score: 0.981

Data Source: BioPlex,Reactome,STRINGDB

H3F3A

Tbio

Novelty: 0.00508186

Score: 0.985

Data Source: STRINGDB

CABIN1

Tbio

Novelty: 0.02528794

Score: 0.983

Data Source: Reactome,STRINGDB

HIRA

Tbio

Novelty: 0.01362595

Score: 0.982

Data Source: Reactome,STRINGDB

HIST1H1B

Tbio

Novelty: 0.00193344

Score: 0.972

Data Source: STRINGDB

HIST1H1C

Tbio

Novelty: 0.00415337

Score: 0.93

Data Source: STRINGDB

HIST1H1D

Tbio

Novelty: 0.00922175

Score: 0.93

Data Source: STRINGDB

HIST1H1E

Tbio

Novelty: 0.01125284

Score: 0.93

Data Source: STRINGDB

H1F0

Tchem

Novelty: 0.00039686

Score: 0.926

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  49.18

PubMed score by year

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PubTator Score  14.29

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Alternative splicing
Cell junction
Chromatin regulator
Coiled coil
Complete proteome
DNA-binding
Host-virus interaction
Nucleus

GWAS Trait Find Similar Targets

body mass index
mean platelet volume
sex hormone-binding globulin measurement
waist-hip ratio

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
mortality/aging