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Tbio
UBN1
Ubinuclein-1

Protein Summary
Description
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262376
  • ENSP00000262376
  • ENSG00000118900
  • ENST00000396658
  • ENSP00000379894
  • ENST00000590769
  • ENSP00000468740

Symbol
  • VT
  • VT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
ligand (protein) perturbation
0.83
transcription factor
0.8
histone modification site profile
0.77
tissue sample
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.18   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.18   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
80.4
waist-hip ratio
1
1
1
59.1
sex hormone-binding globulin measurement
1
1
1
45
mean platelet volume
1
1
1
29.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
80.4
waist-hip ratio
1
59.1
sex hormone-binding globulin measurement
1
45
mean platelet volume
1
29.6
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
DNA Damage/Telomere Stress Induced Senescence
Reactome
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
DNA Damage/Telomere Stress Induced Senescence
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (60)
1 – 10 of 60
ASF1B
Tbio
Novelty: 0.05716701
p_int: 0.999999989
p_ni: 3e-9
p_wrong: 8e-9
Score: 0.483
Data Source: BioPlex,STRINGDB
ASF1A
Tchem
Novelty: 0.02544466
p_int: 0.999999969
p_ni: 1.5e-8
p_wrong: 1.7e-8
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
H3F3A
Tbio
Novelty: 0.00508186
Score: 0.985
Data Source: STRINGDB
CABIN1
Tbio
Novelty: 0.02528794
Score: 0.983
Data Source: Reactome,STRINGDB
HIRA
Tbio
Novelty: 0.01362595
Score: 0.982
Data Source: Reactome,STRINGDB
HIST1H1B
Tbio
Novelty: 0.00193344
Score: 0.972
Data Source: STRINGDB
HIST1H1C
Tbio
Novelty: 0.00415337
Score: 0.93
Data Source: STRINGDB
HIST1H1D
Tbio
Novelty: 0.00922175
Score: 0.93
Data Source: STRINGDB
HIST1H1E
Tbio
Novelty: 0.01125284
Score: 0.93
Data Source: STRINGDB
H1F0
Tchem
Novelty: 0.00039686
Score: 0.926
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  49.18

PubMed score by year
PubTator Score  14.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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