Protein Classes
Protein Summary
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]
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IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 482.69 (req: < 5)
Gene RIFs: 77 (req: <= 3)
Antibodies: 271 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 482.69 (req: >= 5)
Gene RIFs: 77 (req: > 3)
Antibodies: 271 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | neuroglobin | VGNC:12565 | 467518 | |||||
Mouse | MGI:2151886 | 64242 | ||||||
Rat | RGD:621461 | 85382 | ||||||
Dog | neuroglobin | VGNC:43793 | 442944 | |||||
Horse | neuroglobin | VGNC:20724 | 100052130 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | neuroglobin | |||||
Mouse | ||||||
Rat | ||||||
Dog | neuroglobin | |||||
Horse | neuroglobin | |||||
Protein Structure (2 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Intracellular oxygen transport | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Intracellular oxygen transport | ||||
Transport of small molecules | ||||
Gene Ontology Terms (9)
Functions (4)
Components (3)
Processes (2)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (97)
1 – 10 of 97
MPP2
Novelty: 0.0372293
p_int: 0.998551676
p_ni: 0.001448324
Score: 0.285
Data Source: BioPlex,STRINGDB
TRIM32
Family: Enzyme
Novelty: 0.00103526
p_int: 0.988939262
p_ni: 0.011060738
Score: 0.206
Data Source: BioPlex,STRINGDB
CCNB1
Novelty: 0.0005503
p_int: 0.870996301
p_ni: 0.126532297
p_wrong: 0.002471401
Score: 0.228
Data Source: BioPlex,STRINGDB
CYGB
Novelty: 0.0005482
Score: 0.899
Data Source: STRINGDB
MB
Novelty: 0.00008405
Score: 0.867
Data Source: STRINGDB
FLOT1
Novelty: 0.00504569
Score: 0.787
Data Source: STRINGDB
CYCS
Novelty: 0.00014004
Score: 0.747
Data Source: STRINGDB
GBE1
Family: Enzyme
Novelty: 0.00233237
Score: 0.734
Data Source: STRINGDB
CYC1
Novelty: 0.01369865
Score: 0.639
Data Source: STRINGDB
POMT2
Family: Enzyme
Novelty: 0.0251595
Score: 0.635
Data Source: STRINGDB
Publication Statistics
PubMed Score 482.69
PubMed score by year
PubTator Score 267.15
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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