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Tclin
IL23A
Interleukin-23 subunit alpha

Protein Summary
Description
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228534
  • ENSP00000228534
  • ENSG00000110944

Symbol
  • SGRF
  • P19
  • SGRF
  • IL-23
  • IL-23A
  • IL23P19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.97
gene perturbation
0.84
virus perturbation
0.76
transcription factor
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.97   (req: < 5)
Gene RIFs: 244   (req: <= 3)
Antibodies: 601   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.97   (req: >= 5)
Gene RIFs: 244   (req: > 3)
Antibodies: 601   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (49)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-23 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-12 family signaling
Interleukin-23 signaling
Interleukin-4 and Interleukin-13 signaling
Gene Ontology Terms (41)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (124)
1 – 10 of 124
RNF41
Tbio
Family: Enzyme
Novelty: 0.02458297
p_int: 0.994914255
p_ni: 0.004396827
p_wrong: 0.000688918
Score: 0.513
Data Source: BioPlex,STRINGDB
IFFO1
Tdark
Novelty: 0.63157895
p_int: 0.965149062
p_ni: 0.021408688
p_wrong: 0.01344225
Score: 0.323
Data Source: BioPlex,STRINGDB
IL23R
Tbio
Novelty: 0.00752821
Score: 0.996
Data Source: Reactome,STRINGDB
IL12B
Tclin
Novelty: 0.01776322
Score: 0.995
Data Source: Reactome,STRINGDB
IL12RB1
Tbio
Novelty: 0.00474176
Score: 0.967
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00013496
Score: 0.953
Data Source: Reactome,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.00041067
Score: 0.942
Data Source: STRINGDB
STAT4
Tbio
Family: TF
Novelty: 0.00296176
Score: 0.941
Data Source: Reactome,STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.00091233
Score: 0.939
Data Source: STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00331363
Score: 0.931
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  176.97

PubMed score by year
PubTator Score  1144.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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