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Tclin
IL23A
Interleukin-23 subunit alpha

Protein Summary
Description
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228534
  • ENSP00000228534
  • ENSG00000110944

Symbol
  • SGRF
  • P19
  • SGRF
  • IL-23
  • IL-23A
  • IL23P19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.97
gene perturbation
0.84
virus perturbation
0.76
transcription factor
0.7


Related Tools
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.94   (req: < 5)
Gene RIFs: 244   (req: <= 3)
Antibodies: 601   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.94   (req: >= 5)
Gene RIFs: 244   (req: > 3)
Antibodies: 601   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 23 subunit alpha
VGNC:8422
467036
Macaque
interleukin 23 subunit alpha
712627
Mouse
MGI:1932410
83430
Rat
RGD:620873
155140
Dog
interleukin 23 subunit alpha
VGNC:41972
481110
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 23 subunit alpha
Macaque
interleukin 23 subunit alpha
Mouse
Rat
Dog
interleukin 23 subunit alpha
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NPF7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (49)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-23 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-12 family signaling
Interleukin-23 signaling
Interleukin-4 and Interleukin-13 signaling
Gene Ontology Terms (41)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (124)
1 – 10 of 124
RNF41
Tbio
Family: Enzyme
Novelty: 0.01953473
p_int: 0.994914255
p_ni: 0.004396827
p_wrong: 0.000688918
Score: 0.513
Data Source: BioPlex,STRINGDB
IFFO1
Tdark
Novelty: 0.38051741
p_int: 0.965149062
p_ni: 0.021408688
p_wrong: 0.01344225
Score: 0.323
Data Source: BioPlex,STRINGDB
IL23R
Tbio
Novelty: 0.00434717
Score: 0.996
Data Source: Reactome,STRINGDB
IL12B
Tclin
Novelty: 0.0157417
Score: 0.995
Data Source: Reactome,STRINGDB
IL12RB1
Tbio
Novelty: 0.00398741
Score: 0.967
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.953
Data Source: Reactome,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.942
Data Source: STRINGDB
STAT4
Tbio
Family: TF
Novelty: 0.00251747
Score: 0.941
Data Source: Reactome,STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.0007137
Score: 0.939
Data Source: STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.931
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  194.94

PubMed score by year
PubTator Score  1144.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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