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Tbio
CHST11
Carbohydrate sulfotransferase 11

Protein Classes
Protein Summary
Description
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303694
  • ENSP00000305725
  • ENSG00000171310
  • ENST00000549260
  • ENSP00000450004

Symbol
  • C4ST
  • C4ST1
  • OCBMD
  • C4ST-1
  • HSA269537
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor binding site profile
0.93
kinase perturbation
0.91
gene perturbation
0.85
PubMedID
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.45   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.45   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
carbohydrate sulfotransferase 11 [Source:HGNC Symbol;Acc:HGNC:17422]
Mouse
MGI:1927166
58250
Rat
RGD:1308400
314694
Dog
carbohydrate sulfotransferase 11
VGNC:39251
481299
Horse
carbohydrate sulfotransferase 11
VGNC:16534
100067989
Species
Name
OMA
EggNOG
Inparanoid
Macaque
carbohydrate sulfotransferase 11 [Source:HGNC Symbol;Acc:HGNC:17422]
Mouse
Rat
Dog
carbohydrate sulfotransferase 11
Horse
carbohydrate sulfotransferase 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NPF2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Chondroitin sulfate biosynthesis (R-HSA-2022870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Glycosaminoglycan metabolism
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (60)
1 – 10 of 60
SDF4
Tbio
Novelty: 0.00105893
p_int: 0.997229783
p_ni: 0.00242944
p_wrong: 0.000340777
Score: 0.188
Data Source: BioPlex,STRINGDB
HLA-DPA1
Tbio
Novelty: 0.01080446
p_int: 0.830219542
p_ni: 0.000103102
p_wrong: 0.169677355
Score: 0.231
Data Source: BioPlex,STRINGDB
SLC2A12
Tbio
Family: Transporter
Novelty: 0.01455533
p_int: 0.797985696
p_ni: 0.000096511
p_wrong: 0.201917793
Score: 0.179
Data Source: BioPlex,STRINGDB
CHST3
Tbio
Family: Enzyme
Novelty: 0.01744095
Score: 0.971
Data Source: STRINGDB
CHST15
Tbio
Family: Enzyme
Novelty: 0.03950241
Score: 0.97
Data Source: STRINGDB
CHST7
Tbio
Family: Enzyme
Novelty: 0.18769086
Score: 0.961
Data Source: STRINGDB
VCAN
Tbio
Novelty: 0.00110986
Score: 0.96
Data Source: STRINGDB
UST
Tbio
Family: Enzyme
Novelty: 0.03897672
Score: 0.957
Data Source: STRINGDB
NCAN
Tbio
Novelty: 0.00401824
Score: 0.939
Data Source: STRINGDB
DCN
Tbio
Novelty: 0.00073027
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  44.45

PubMed score by year
PubTator Score  22.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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