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Tbio
CD320
CD320 antigen

Protein Summary
Description
Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631). This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301458
  • ENSP00000301458
  • ENSG00000167775
  • ENST00000537716
  • ENSP00000437697

Symbol
  • 8D6A
  • 8D6
  • 8D6A
  • TCBLR
  • TCN2R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
pathway
0.78
disease perturbation
0.74
transcription factor binding site profile
0.73
cellular component
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.58   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.58   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD320 molecule
VGNC:2367
456436
Macaque
CD320 molecule
711130
Mouse
MGI:1860083
54219
Rat
RGD:1305860
362851
Dog
CD320 molecule
VGNC:38949
100855567
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD320 molecule
Macaque
CD320 molecule
Mouse
Rat
Dog
CD320 molecule
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NPF0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Cobalamin (Cbl, vitamin B12) transport and metabolism (R-HSA-196741)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome
Defective CD320 causes methylmalonic aciduria
Reactome
Defects in cobalamin (B12) metabolism
Reactome
Defects in vitamin and cofactor metabolism
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cobalamin (Cbl, vitamin B12) transport and metabolism
Defective CD320 causes methylmalonic aciduria
Defects in cobalamin (B12) metabolism
Defects in vitamin and cofactor metabolism
Disease
Protein-Protein Interactions (54)
1 – 10 of 54
TMX1
Tbio
Novelty: 0.03444237
p_int: 0.999794811
p_ni: 0.000204223
p_wrong: 9.65e-7
Data Source: BioPlex
TM4SF18
Tbio
Novelty: 0.16102348
p_int: 0.996338439
p_ni: 0.003661364
p_wrong: 1.98e-7
Score: 0.165
Data Source: BioPlex,STRINGDB
TSPAN3
Tbio
Novelty: 0.06362133
p_int: 0.985911913
p_ni: 0.010357795
p_wrong: 0.003730292
Data Source: BioPlex
ARRDC3
Tbio
Novelty: 0.04840692
p_int: 0.985539055
p_ni: 0.010598982
p_wrong: 0.003861964
Data Source: BioPlex
TPCN2
Tchem
Family: IC
Novelty: 0.01351129
p_int: 0.972039885
p_ni: 0.025309876
p_wrong: 0.002650239
Data Source: BioPlex
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.952653471
p_ni: 0.043151715
p_wrong: 0.004194813
Data Source: BioPlex
IFNGR1
Tbio
Novelty: 0.00417244
p_int: 0.947081282
p_ni: 0.052867445
p_wrong: 0.000051273
Data Source: BioPlex
IL2RG
Tclin
Novelty: 0.00108272
p_int: 0.928431385
p_ni: 0.071564676
p_wrong: 0.000003939
Score: 0.189
Data Source: BioPlex,STRINGDB
LTBR
Tbio
Novelty: 0.003823
p_int: 0.924591898
p_ni: 0.075406758
p_wrong: 0.000001344
Data Source: BioPlex
LITAF
Tbio
Family: TF
Novelty: 0.0097203
p_int: 0.923388706
p_ni: 0.076609956
p_wrong: 0.000001338
Data Source: BioPlex
Publication Statistics
PubMed Score  55.58

PubMed score by year
PubTator Score  26.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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