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Tbio
NRN1
Neuritin

Protein Summary
Description
Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244766
  • ENSP00000244766
  • ENSG00000124785
  • ENST00000616243
  • ENSP00000484055

Symbol
  • NRN
  • NRN
  • dJ380B8.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
PubMedID
0.68
small molecule perturbation
0.61
transcription factor binding site profile
0.61
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.01   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.01   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
RAET1E
Tbio
Novelty:  0.01859274
p_int:  0.999918176
p_ni:  0.000081325
p_wrong:  5e-7
Data Source:  BioPlex
SLC12A6
Tbio
Family:  Transporter
Novelty:  0.0132619
p_int:  0.999915482
p_ni:  0.000084518
Score:  0.158
Data Source:  BioPlex,STRINGDB
SLC12A7
Tbio
Family:  Transporter
Novelty:  0.02248904
p_int:  0.999888755
p_ni:  0.000111245
Score:  0.167
Data Source:  BioPlex,STRINGDB
NCEH1
Tchem
Family:  Enzyme
Novelty:  0.01528589
p_int:  0.999723887
p_ni:  0.00021586
p_wrong:  0.000060252
Data Source:  BioPlex
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.999555327
p_ni:  0.000422299
p_wrong:  0.000022374
Data Source:  BioPlex
LRRC52
Tbio
Family:  IC
Novelty:  0.15407898
p_int:  0.999524938
p_ni:  0.000474807
p_wrong:  2.56e-7
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.999444485
p_ni:  0.000547028
p_wrong:  0.000008487
Data Source:  BioPlex
DUSP22
Tbio
Family:  Enzyme
Novelty:  0.01579003
p_int:  0.999259571
p_ni:  0.000715971
p_wrong:  0.000024458
Data Source:  BioPlex
TMEM219
Tdark
Novelty:  0.33292987
p_int:  0.999130524
p_ni:  0.000869475
p_wrong:  1e-9
Data Source:  BioPlex
PCDHGC3
Tbio
Novelty:  0.07203024
p_int:  0.998741853
p_ni:  0.00125682
p_wrong:  0.000001327
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuritin 1
VGNC:3598
462412
Macaque
neuritin 1
722968
Mouse
MGI:1915654
68404
Rat
RGD:621586
83834
Dog
neuritin 1
VGNC:43973
612757
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuritin 1
Macaque
neuritin 1
Mouse
Rat
Dog
neuritin 1
Publication Statistics
PubMed Score 98.01
PubMed score by year
PubTator Score 42.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title