Protein Summary
Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000244766
- ENSP00000244766
- ENSG00000124785
- ENST00000616243
- ENSP00000484055
- NRN
- NRN
- dJ380B8.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.81 | ||
PubMedID | 0.68 | ||
small molecule perturbation | 0.61 | ||
transcription factor binding site profile | 0.61 | ||
transcription factor perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 98.01 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 169 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 98.01 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 169 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (117)
RAET1E
Novelty: 0.01859274
p_int: 0.999918176
p_ni: 0.000081325
p_wrong: 5e-7
Data Source: BioPlex
SLC12A6
Family: Transporter
Novelty: 0.0132619
p_int: 0.999915482
p_ni: 0.000084518
Score: 0.158
Data Source: BioPlex,STRINGDB
SLC12A7
Family: Transporter
Novelty: 0.02248904
p_int: 0.999888755
p_ni: 0.000111245
Score: 0.167
Data Source: BioPlex,STRINGDB
NCEH1
Family: Enzyme
Novelty: 0.01528589
p_int: 0.999723887
p_ni: 0.00021586
p_wrong: 0.000060252
Data Source: BioPlex
GJB7
Novelty: 0.12555147
p_int: 0.999555327
p_ni: 0.000422299
p_wrong: 0.000022374
Data Source: BioPlex
LRRC52
Family: IC
Novelty: 0.15407898
p_int: 0.999524938
p_ni: 0.000474807
p_wrong: 2.56e-7
Data Source: BioPlex
DUSP22
Family: Enzyme
Novelty: 0.01579003
p_int: 0.999259571
p_ni: 0.000715971
p_wrong: 0.000024458
Data Source: BioPlex
TMEM219
Novelty: 0.33292987
p_int: 0.999130524
p_ni: 0.000869475
p_wrong: 1e-9
Data Source: BioPlex
PCDHGC3
Novelty: 0.07203024
p_int: 0.998741853
p_ni: 0.00125682
p_wrong: 0.000001327
Score: 0.161
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational modification: synthesis of GPI-anchored proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational modification: synthesis of GPI-anchored proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Components (5)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | neuritin 1 | VGNC:3598 | 462412 | |||||
Macaque | neuritin 1 | 722968 | ||||||
Mouse | MGI:1915654 | 68404 | ||||||
Rat | RGD:621586 | 83834 | ||||||
Dog | neuritin 1 | VGNC:43973 | 612757 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | neuritin 1 | |||||
Macaque | neuritin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | neuritin 1 | |||||
Publication Statistics
PubMed Score 98.01
PubMed score by year
PubTator Score 42.61
PubTator score by year
Related Publications
Text Mined References (20)
GeneRif Annotations (14)
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