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Tchem
SLCO1B3
Solute carrier organic anion transporter family member 1B3

Protein Summary
Description
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver. This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261196
  • ENSP00000261196
  • ENSG00000111700
  • ENST00000381545
  • ENSP00000370956

Symbol
  • LST2
  • OATP1B3
  • OATP8
  • SLC21A8
  • LST3
  • HBLRR
  • LST-2
  • OATP8
  • OATP-8
  • OATP1B3
  • SLC21A8
  • LST-3TM13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.95
cell type or tissue
0.8
biological term
0.78
chemical
0.68
disease
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.82   (req: < 5)
Gene RIFs: 109   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.82   (req: >= 5)
Gene RIFs: 109   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (9)
paclitaxel
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ciclosporin
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sildenafil
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losartan
Rendered image for losartan
telmisartan
Rendered image for telmisartan
hydroxyzine
Rendered image for hydroxyzine
enoxolone
Rendered image for enoxolone
mometasone furoate
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olmesartan medoxomil
Rendered image for olmesartan medoxomil
Active Ligands (18)
arachidonic acid
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US9090657, DEBIO-025, 2
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US9090657, Cyclosporine A, 1
Rendered image for US9090657, Cyclosporine A, 1
NIM258
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rifampicin
Rendered image for rifampicin
CHEMBL4637446
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CHEMBL4636474
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CHEMBL4633668
Rendered image for CHEMBL4633668
SMILAGENIN
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OLIGOMYCIN (A shown)
Rendered image for OLIGOMYCIN (A shown)
Protein-Protein Interactions (60)
SLC10A1
Tclin
Family:  Transporter
Novelty:  0.00142951
Score:  0.857
Data Source:  STRINGDB
SLC22A7
Tbio
Family:  Transporter
Novelty:  0.00964024
Score:  0.825
Data Source:  STRINGDB
ABCC2
Tchem
Family:  Transporter
Novelty:  0.00110828
Score:  0.815
Data Source:  STRINGDB
SLC22A8
Tclin
Family:  Transporter
Novelty:  0.00291642
Score:  0.797
Data Source:  STRINGDB
ABCB11
Tchem
Family:  Transporter
Novelty:  0.00097529
Score:  0.78
Data Source:  STRINGDB
BLVRA
Tbio
Family:  Enzyme
Novelty:  0.00526407
Score:  0.764
Data Source:  STRINGDB
SLC22A1
Tchem
Family:  Transporter
Novelty:  0.00427728
Score:  0.753
Data Source:  STRINGDB
ABCG2
Tchem
Family:  Transporter
Novelty:  0.00029779
Score:  0.744
Data Source:  STRINGDB
ABCC3
Tbio
Family:  Transporter
Novelty:  0.00260166
Score:  0.738
Data Source:  STRINGDB
ABCB1
Tchem
Family:  Transporter
Novelty:  0.00018144
Score:  0.707
Data Source:  STRINGDB
Pathways (14)
Bile acid and bile salt metabolism (R-HSA-194068)

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Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
Disease
Disorders of transmembrane transporters
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
8
22
41
99.6
serum gamma-glutamyl transferase measurement
1
1
1
85.4
serum alanine aminotransferase measurement
2
2
1
7.2
84.5
metabolite measurement
1
4
4
70.8
aspartate aminotransferase measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
41
99.6
serum gamma-glutamyl transferase measurement
1
85.4
serum alanine aminotransferase measurement
1
7.2
84.5
metabolite measurement
4
70.8
aspartate aminotransferase measurement
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 222.82
PubMed score by year
PubTator Score 233.70
PubTator score by year
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Related Publications
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PMID
Year
Title