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Tbio
EXOSC4
Exosome complex component RRP41

Protein Summary
Description
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316052
  • ENSP00000315476
  • ENSG00000178896

Symbol
  • RRP41
  • SKI6
  • SKI6
  • p12A
  • RRP41
  • Ski6p
  • RRP41A
  • Rrp41p
  • hRrp41p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
transcription factor binding site profile
0.89
kinase perturbation
0.84
transcription factor perturbation
0.8
disease perturbation
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.14   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.14   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exosome component 4
VGNC:879
740889
Macaque
exosome component 4
700012
Mouse
MGI:1923576
109075
Rat
RGD:1310986
300045
Dog
exosome component 4
VGNC:40525
482086
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exosome component 4
Macaque
exosome component 4
Mouse
Rat
Dog
exosome component 4
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
KSRP (KHSRP) binds and destabilizes mRNA
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Deadenylation-dependent mRNA decay
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Gene Ontology Terms (26)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (250)
1 – 10 of 250
C1D
Tbio
Novelty: 0.00997109
p_int: 0.999952114
p_ni: 0.000047886
Score: 0.998
Data Source: BioPlex,STRINGDB
MPHOSPH6
Tbio
Family: Enzyme
Novelty: 0.24387167
p_int: 0.999916014
p_ni: 0.000083986
Score: 0.998
Data Source: BioPlex,STRINGDB
EXOSC1
Tbio
Novelty: 0.01386842
p_int: 0.997632381
p_ni: 0.002367619
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC3
Tbio
Novelty: 0.03072164
p_int: 0.992704265
p_ni: 0.007295735
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC7
Tbio
Family: Enzyme
Novelty: 0.07422851
p_int: 0.988103928
p_ni: 0.011896072
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC8
Tbio
Family: Enzyme
Novelty: 0.02013403
p_int: 0.876957715
p_ni: 0.123042285
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC5
Tbio
Family: Enzyme
Novelty: 0.03352493
Score: 0.999
Data Source: STRINGDB
DIS3L
Tdark
Family: Enzyme
Novelty: 0.12886408
Score: 0.999
Data Source: STRINGDB
EXOSC9
Tbio
Family: Enzyme
Novelty: 0.02405093
Score: 0.999
Data Source: STRINGDB
DIS3
Tbio
Family: Enzyme
Novelty: 0.00961238
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  118.14

PubMed score by year
PubTator Score  25.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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