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Tbio
A4GALT
Lactosylceramide 4-alpha-galactosyltransferase

Protein Summary
Description
Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins. The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. This protein, a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249005
  • ENSP00000249005
  • ENSG00000128274
  • ENST00000381278
  • ENSP00000370678
  • ENST00000401850
  • ENSP00000384794
  • ENST00000642412
  • ENSP00000494127

Symbol
  • A14GALT
  • A4GALT1
  • P1
  • PK
  • Gb3S
  • P(k)
  • P1PK
  • A14GALT
  • A4GALT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.86
small molecule perturbation
0.66
histone modification site profile
0.63
PubMedID
0.59
tissue
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.95   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.95   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
ICK
Tchem
Family:  Kinase
Novelty:  0.00810476
p_int:  0.948672296
p_ni:  0.000793632
p_wrong:  0.050534072
Score:  0.191
Data Source:  BioPlex,STRINGDB
ABHD14A
Tdark
Family:  Enzyme
Novelty:  0.77988335
p_int:  0.894867248
p_ni:  0.105122593
p_wrong:  0.000010159
Score:  0.252
Data Source:  BioPlex,STRINGDB
ABHD17B
Tbio
Family:  Enzyme
Novelty:  0.64360453
p_int:  0.840473017
p_ni:  0.157528922
p_wrong:  0.001998061
Score:  0.519
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.790994057
p_ni:  0.209005943
Data Source:  BioPlex
B3GALNT1
Tbio
Family:  Enzyme
Novelty:  0.01235828
Score:  0.99
Data Source:  STRINGDB
B4GALT1
Tbio
Family:  Enzyme
Novelty:  0.0073693
Score:  0.928
Data Source:  STRINGDB
B4GALT4
Tbio
Family:  Enzyme
Novelty:  0.11226614
Score:  0.921
Data Source:  STRINGDB
B4GALT2
Tbio
Family:  Enzyme
Novelty:  0.03492512
Score:  0.913
Data Source:  STRINGDB
B4GALT3
Tbio
Family:  Enzyme
Novelty:  0.04015046
Score:  0.912
Data Source:  STRINGDB
HEXB
Tchem
Family:  Enzyme
Novelty:  0.0085045
Score:  0.91
Data Source:  STRINGDB
Pathways (5)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Metabolic pathways
KEGG
Glycosphingolipid biosynthesis - globo and isoglobo series
KEGG
Glycosphingolipid biosynthesis - lacto and neolacto series
Name
Explore in Pharos
Explore in Source
Metabolic pathways
Glycosphingolipid biosynthesis - globo and isoglobo series
Glycosphingolipid biosynthesis - lacto and neolacto series
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
4
4
94.8
hematocrit
3
3
3
94.2
hemoglobin measurement
3
2
3
92.6
mean platelet volume
2
3
3
91.1
red blood cell density measurement
1
1
1
85.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
94.8
hematocrit
3
94.2
hemoglobin measurement
3
92.6
mean platelet volume
3
91.1
red blood cell density measurement
1
85.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha 1,4-galactosyltransferase
VGNC:53397
470230
Mouse
MGI:3512453
239559
Rat
RGD:621583
63888
Dog
alpha 1,4-galactosyltransferase (P blood group)
481222
Cow
alpha 1,4-galactosyltransferase
VGNC:49133
618369
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha 1,4-galactosyltransferase
Mouse
Rat
Dog
alpha 1,4-galactosyltransferase (P blood group)
Cow
alpha 1,4-galactosyltransferase
Publication Statistics
PubMed Score 106.95
PubMed score by year
PubTator Score 516.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title