CCNB1IP1
E3 ubiquitin-protein ligase CCNB1IP1
Protein Summary
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2 ...more
- ENST00000353689
- ENSP00000337396
- ENSG00000100814
- ENST00000358932
- ENSP00000351810
- ENST00000398160
- ENSP00000381226
- ENST00000398163
- ENSP00000381229
- ENST00000398169
- ENSP00000381235
- ENST00000437553
- ENSP00000409896
- C14orf18
- HEI10
- HEI10
- C14orf18
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.68 | ||
tissue sample | 0.58 | ||
transcription factor | 0.54 | ||
cell line | 0.52 | ||
small molecule perturbation | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.54 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 207 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.54 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 207 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (57)
HIST1H1D
Novelty: 0.00922175
p_int: 0.99812848
p_ni: 0.001871453
p_wrong: 6.7e-8
Score: 0.507
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (156)
UniProt (1)
WikiPathways (155)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
UniProt | Protein modification; protein ubiquitination. | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Protein modification; protein ubiquitination. | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (1)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.6 | 27.3 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.6 | 27.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cyclin B1 interacting protein 1 | VGNC:9041 | 740744 | |||||
Macaque | cyclin B1 interacting protein 1 | 703502 | ||||||
Mouse | MGI:2685134 | 239083 | ||||||
Rat | RGD:1561930 | 498492 | ||||||
Dog | cyclin B1 interacting protein 1 | VGNC:38894 | 482554 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cyclin B1 interacting protein 1 | |||||
Macaque | cyclin B1 interacting protein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cyclin B1 interacting protein 1 | |||||
Publication Statistics
PubMed Score 32.54
PubMed score by year
PubTator Score 7.42
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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