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Tbio
CCNB1IP1
E3 ubiquitin-protein ligase CCNB1IP1

Protein Summary
Description
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353689
  • ENSP00000337396
  • ENSG00000100814
  • ENST00000358932
  • ENSP00000351810
  • ENST00000398160
  • ENSP00000381226
  • ENST00000398163
  • ENSP00000381229
  • ENST00000398169
  • ENSP00000381235
  • ENST00000437553
  • ENSP00000409896

Symbol
  • C14orf18
  • HEI10
  • HEI10
  • C14orf18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
tissue sample
0.58
transcription factor
0.54
cell line
0.52
small molecule perturbation
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.54   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.54   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
HIST1H1D
Tbio
Novelty:  0.00922175
p_int:  0.99812848
p_ni:  0.001871453
p_wrong:  6.7e-8
Score:  0.507
Data Source:  BioPlex,STRINGDB
RNF212
Tbio
Family:  Enzyme
Novelty:  0.05189831
Score:  0.863
Data Source:  STRINGDB
MSH4
Tbio
Novelty:  0.00838156
Score:  0.863
Data Source:  STRINGDB
RNF212B
Tdark
Novelty:  1.20319873
Score:  0.838
Data Source:  STRINGDB
MSH5
Tbio
Novelty:  0.0109825
Score:  0.82
Data Source:  STRINGDB
MLH3
Tbio
Novelty:  0.01295793
Score:  0.766
Data Source:  STRINGDB
HFM1
Tbio
Family:  Enzyme
Novelty:  0.01556527
Score:  0.76
Data Source:  STRINGDB
COX6C
Tbio
Family:  Enzyme
Novelty:  0.04365165
Score:  0.754
Data Source:  STRINGDB
CNTD1
Tbio
Novelty:  0.22055841
Score:  0.733
Data Source:  STRINGDB
EPM2AIP1
Tdark
Novelty:  0.1803524
Score:  0.723
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (156)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin B1 interacting protein 1
VGNC:9041
740744
Macaque
cyclin B1 interacting protein 1
703502
Mouse
MGI:2685134
239083
Rat
RGD:1561930
498492
Dog
cyclin B1 interacting protein 1
VGNC:38894
482554
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin B1 interacting protein 1
Macaque
cyclin B1 interacting protein 1
Mouse
Rat
Dog
cyclin B1 interacting protein 1
Publication Statistics
PubMed Score 32.54
PubMed score by year
PubTator Score 7.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title