Tbio CCNB1IP1 E3 ubiquitin-protein ligase CCNB1IP1

Protein Summary

Description

Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q9NPC3

Gene Name

• CCNB1IP1

Ensembl ID

• ENST00000353689
• ENSP00000337396
• ENSG00000100814
• ENST00000358932
• ENSP00000351810
• ENST00000398160
• ENSP00000381226
• ENST00000398163
• ENSP00000381229
• ENST00000398169
• ENSP00000381235
• ENST00000437553
• ENSP00000409896

Symbol

• C14orf18
• HEI10
• HEI10
• C14orf18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.68
tissue sample	0.58
transcription factor	0.54
cell line	0.52
small molecule perturbation	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.9   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 207   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.9   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0