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Tclin
KCNK9
Potassium channel subfamily K member 9

Protein Summary
Description
pH-dependent, voltage-insensitive, background potassium channel protein. This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303015
  • ENSP00000302166
  • ENSG00000169427
  • ENST00000520439
  • ENSP00000430676
  • ENST00000522317
  • ENSP00000429847
  • ENST00000648164
  • ENSP00000498198
  • ENST00000650269
  • ENSP00000496915

Symbol
  • TASK3
  • KT3.2
  • TASK3
  • K2p9.1
  • TASK-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
cell line
0.68
hub protein
0.58
protein domain
0.58
tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.12   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.12   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 43
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6