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Tclin
KCNK9
Potassium channel subfamily K member 9

Protein Summary
Description
pH-dependent, voltage-insensitive, background potassium channel protein. This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303015
  • ENSP00000302166
  • ENSG00000169427
  • ENST00000520439
  • ENSP00000430676
  • ENST00000522317
  • ENSP00000429847
  • ENST00000648164
  • ENSP00000498198
  • ENST00000650269
  • ENSP00000496915

Symbol
  • TASK3
  • KT3.2
  • TASK3
  • K2p9.1
  • TASK-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
cell line
0.68
hub protein
0.58
protein domain
0.58
tissue
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.1   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.1   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
56.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
potassium two pore domain channel subfamily K member 9
100425983
Mouse
MGI:3521816
223604
Rat
RGD:621451
84429
Dog
potassium two pore domain channel subfamily K member 9
VGNC:42280
482057
Horse
potassium two pore domain channel subfamily K member 9
VGNC:19302
100058202
Species
Name
OMA
EggNOG
Inparanoid
Macaque
potassium two pore domain channel subfamily K member 9
Mouse
Rat
Dog
potassium two pore domain channel subfamily K member 9
Horse
potassium two pore domain channel subfamily K member 9
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NPC2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (65)
1 – 10 of 65
KCNK3
Tclin
Family: IC
Novelty: 0.00324494
Score: 0.907
Data Source: Reactome,STRINGDB
GYG1
Tbio
Family: Enzyme
Novelty: 0.01446978
Score: 0.807
Data Source: STRINGDB
NUDT6
Tbio
Novelty: 0.03648851
Score: 0.804
Data Source: STRINGDB
KCNJ9
Tbio
Family: IC
Novelty: 0.02279401
Score: 0.662
Data Source: STRINGDB
DLGAP2
Tbio
Novelty: 0.02137009
Score: 0.638
Data Source: STRINGDB
KCNA1
Tclin
Family: IC
Novelty: 0.00183322
Score: 0.629
Data Source: STRINGDB
KCNH1
Tclin
Family: IC
Novelty: 0.00271053
Score: 0.6
Data Source: STRINGDB
KCNA3
Tclin
Family: IC
Novelty: 0.00169224
Score: 0.595
Data Source: STRINGDB
DPP6
Tbio
Family: Enzyme
Novelty: 0.00435138
Score: 0.595
Data Source: STRINGDB
KCNJ10
Tbio
Family: IC
Novelty: 0.00273462
Score: 0.593
Data Source: STRINGDB
Publication Statistics
PubMed Score  178.10

PubMed score by year
PubTator Score  165.33

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer