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Tchem
LTB4R2
Leukotriene B4 receptor 2

Protein Summary
Description
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000528054
  • ENSP00000432146
  • ENSG00000213906
  • ENST00000533293
  • ENSP00000433290
  • ENST00000543919
  • ENSP00000445772
  • ENST00000643080
  • ENSP00000494694
  • ENSG00000285203
  • ENST00000644309
  • ENSP00000494877
  • ENST00000645084
  • ENSP00000496382

Symbol
  • BLT2R
  • BLTR2
  • BLT2
  • NOP9
  • BLTR2
  • JULF2
  • KPG_004
  • LTB4-R2
  • LTB4-R 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.63
protein domain
0.58
cell line
0.55
tissue sample
0.54
biological process
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.08   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.08   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (187)
CYSLTR2
Tchem
Family:  GPCR
Novelty:  0.00895224
Score:  0.977
Data Source:  STRINGDB
PTGER1
Tclin
Family:  GPCR
Novelty:  0.0013716
Score:  0.942
Data Source:  STRINGDB
TBXA2R
Tclin
Family:  GPCR
Novelty:  0.00571066
Score:  0.938
Data Source:  STRINGDB
CYSLTR1
Tclin
Family:  GPCR
Novelty:  0.00337777
Score:  0.933
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.923
Data Source:  STRINGDB
HRH1
Tclin
Family:  GPCR
Novelty:  0.00073548
Score:  0.922
Data Source:  STRINGDB
GPR132
Tchem
Family:  GPCR
Novelty:  0.00453902
Score:  0.922
Data Source:  STRINGDB
PTAFR
Tchem
Family:  GPCR
Novelty:  0.00755426
Score:  0.922
Data Source:  STRINGDB
GPR17
Tchem
Family:  GPCR
Novelty:  0.00545502
Score:  0.921
Data Source:  STRINGDB
LTB4R
Tchem
Family:  GPCR
Novelty:  0.00354427
Score:  0.919
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
34
4
35
97.1
telomere length
1
1
1
92.4
sex hormone-binding globulin measurement
10
1
9
16.3
87.3
C-reactive protein measurement
4
3
4
86.9
appendicular lean mass
1
2
2
82.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
35
97.1
telomere length
1
92.4
sex hormone-binding globulin measurement
9
16.3
87.3
C-reactive protein measurement
4
86.9
appendicular lean mass
2
82.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leukotriene B4 receptor 2
VGNC:12558
745736
Macaque
leukotriene B4 receptor 2
716012
Mouse
MGI:1888501
57260
Rat
RGD:621029
114098
Cow
leukotriene B4 receptor 2
VGNC:31070
513386
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leukotriene B4 receptor 2
Macaque
leukotriene B4 receptor 2
Mouse
Rat
Cow
leukotriene B4 receptor 2
Publication Statistics
PubMed Score 118.08
PubMed score by year
PubTator Score 63.38
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title