You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ACKR4
Atypical chemokine receptor 4

Protein Summary
Description
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus. The protein encoded by this gene is a member of the G protein-coupled receptor family, and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249887
  • ENSP00000249887
  • ENSG00000129048

Symbol
  • CCBP2
  • CCR11
  • CCRL1
  • VSHK1
  • PPR1
  • CCBP2
  • CCR10
  • CCR11
  • CCRL1
  • VSHK1
  • CCR-11
  • CKR-11
  • CCX CKR
  • CCX-CKR
  • CC-CKR-11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.75
ligand (protein)
0.68
cell type or tissue
0.67
molecular function
0.63
tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.13   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.13   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0