Tbio PARD6A Partitioning defective 6 homolog alpha

Protein Summary

Description

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NPB6
• O14911
• Q9NPJ7
• PAR-6

Gene Name

• PARD6A

Ensembl ID

• ENST00000219255
• ENSP00000219255
• ENSG00000102981
• ENST00000458121
• ENSP00000392388

Symbol

• PAR6A
• PAR6
• PAR6C
• TAX40
• PAR-6A
• TIP-40
• PAR6alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.78
tissue sample	0.76
disease perturbation	0.74
histone modification site profile	0.68
transcription factor binding site profile	0.63

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Tight Junction / Partitioning Defective 6 Homolog Alpha

DTO Classes

Protein / Cell-cell Junction / Tight Junction / Partitioning Defective 6 Homolog Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.69   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 267   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.69   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0