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Tbio
PARD6A
Partitioning defective 6 homolog alpha

Protein Summary
Description
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated wit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219255
  • ENSP00000219255
  • ENSG00000102981
  • ENST00000458121
  • ENSP00000392388

Symbol
  • PAR6A
  • PAR6
  • PAR6C
  • TAX40
  • PAR-6A
  • TIP-40
  • PAR6alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.78
tissue sample
0.76
disease perturbation
0.74
histone modification site profile
0.68
transcription factor binding site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.94   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.94   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
PRKCZ
Tchem
Family:  Kinase
Novelty:  0.00201366
p_int:  0.897503631
p_ni:  9.3e-8
p_wrong:  0.102496276
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.998
Data Source:  STRINGDB
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
Score:  0.997
Data Source:  Reactome,STRINGDB
PARD3
Tbio
Novelty:  0.00521327
Score:  0.996
Data Source:  Reactome,STRINGDB
LLGL2
Tbio
Novelty:  0.07084531
Score:  0.99
Data Source:  STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.966
Data Source:  Reactome,STRINGDB
SMURF1
Tchem
Family:  Enzyme
Novelty:  0.00754708
Score:  0.965
Data Source:  Reactome,STRINGDB
F2RL2
Tbio
Family:  GPCR
Novelty:  0.2305357
Score:  0.96
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.958
Data Source:  STRINGDB
NUMB
Tbio
Novelty:  0.00211228
Score:  0.955
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (80)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
2
2
90.2
sleep duration
1
1
1
79.9
lymphocyte count
2
1
2
78.1
serum non-albumin protein measurement
1
1
1
71.9
red blood cell distribution width
1
1
1
59.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
90.2
sleep duration
1
79.9
lymphocyte count
2
78.1
serum non-albumin protein measurement
1
71.9
red blood cell distribution width
1
59.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
par-6 family cell polarity regulator alpha
VGNC:8990
454171
Mouse
MGI:1927223
56513
Rat
RGD:1303273
307799
Dog
par-6 family cell polarity regulator alpha
VGNC:44265
489756
Horse
par-6 family cell polarity regulator alpha
VGNC:21162
100053411
Species
Name
OMA
EggNOG
Inparanoid
Chimp
par-6 family cell polarity regulator alpha
Mouse
Rat
Dog
par-6 family cell polarity regulator alpha
Horse
par-6 family cell polarity regulator alpha
Publication Statistics
PubMed Score 20.94
PubMed score by year
PubTator Score 18.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title