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Tbio
CABP2
Calcium-binding protein 2

Protein Classes
Protein Summary
Description
Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs (PubMed:28183797). Required for the normal transfer of light signals through the retina (By similarity). This gene belongs to a subfamily of calcium binding proteins that share similarity to calmodulin. Like calmodulin, these family members can likely stimulate calmodulin-dependent kinase II and the protein phosphatase calcineurin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294288
  • ENSP00000294288
  • ENSG00000167791
  • ENST00000353903
  • ENSP00000312037

Symbol
  • DFNB93
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
protein domain
0.58
cell line
0.55
gene perturbation
0.51
cellular component
0.46


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.76   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.76   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium binding protein 2
VGNC:3192
466683
Macaque
calcium binding protein 2
721708
Mouse
MGI:1352749
29866
Rat
RGD:1563670
499298
Dog
calcium binding protein 2
VGNC:38624
611821
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium binding protein 2
Macaque
calcium binding protein 2
Mouse
Rat
Dog
calcium binding protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NPB3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (44)
1 – 10 of 44
RIBC1
Tdark
Novelty: 0.40435429
Score: 0.711
Data Source: STRINGDB
GRK5
Tchem
Family: Kinase
Novelty: 0.01108012
Score: 0.706
Data Source: STRINGDB
TERB2
Tdark
Novelty: 0.39092243
Score: 0.695
Data Source: STRINGDB
C1orf43
Tbio
Novelty: 0.13587458
Score: 0.681
Data Source: STRINGDB
CACNA1D
Tclin
Family: IC
Novelty: 0.00314752
Score: 0.655
Data Source: STRINGDB
HAND2
Tbio
Family: TF
Novelty: 0.00478924
Score: 0.641
Data Source: STRINGDB
MYH10
Tbio
Novelty: 0.00624251
Score: 0.634
Data Source: STRINGDB
FBXO22
Tbio
Novelty: 0.12033872
Score: 0.616
Data Source: STRINGDB
CACNA1F
Tchem
Family: IC
Novelty: 0.00431963
Score: 0.604
Data Source: STRINGDB
OBSCN
Tbio
Family: Kinase
Novelty: 0.01173699
Score: 0.601
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.76

PubMed score by year
PubTator Score  4.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer