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Tchem
NT5M
5'(3')-deoxyribonucleotidase, mitochondrial

Protein Summary
Description
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389022
  • ENSP00000373674
  • ENSG00000205309

Symbol
  • DNT2
  • mdN
  • dNT2
  • dNT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
cell type or tissue
0.72
small molecule perturbation
0.66
transcription factor binding site profile
0.66
tissue sample
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.96   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.96   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3752084
chemical structure image
Protein Data Bank (21)
1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Pyrimidine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Pyrimidine catabolism
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (136)
1 – 10 of 136
TYMP
Tclin
Family: Enzyme
Novelty: 0.0015906
Score: 0.969
Data Source: STRINGDB
AK3
Tbio
Family: Kinase
Novelty: 0.02673466
Score: 0.969
Data Source: STRINGDB
CMPK2
Tbio
Family: Kinase
Novelty: 0.01285082
Score: 0.951
Data Source: STRINGDB
DTYMK
Tbio
Family: Kinase
Novelty: 0.00746576
Score: 0.947
Data Source: STRINGDB
ITPA
Tbio
Family: Enzyme
Novelty: 0.00235169
Score: 0.938
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.938
Data Source: STRINGDB
NT5C1A
Tbio
Family: Enzyme
Novelty: 0.00634411
Score: 0.933
Data Source: STRINGDB
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
Score: 0.931
Data Source: STRINGDB
NT5C1B
Tbio
Family: Enzyme
Novelty: 0.09140009
Score: 0.928
Data Source: STRINGDB
NT5C2
Tbio
Family: Enzyme
Novelty: 0.00758288
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.96

PubMed score by year
PubTator Score  14.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer