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Tbio
ENY2
Transcription and mRNA export factor ENY2

Protein Summary
Description
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000521662
  • ENSP00000429713
  • ENSG00000120533
  • ENST00000521688
  • ENSP00000429986

Symbol
  • DC6
  • Sus1
  • e(y)2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
transcription factor binding site profile
0.88
histone modification site profile
0.8
biological process
0.74
virus perturbation
0.68


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.17   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.17   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ENY2, transcription and export complex 2 subunit
VGNC:10491
735847
Macaque
ENY2, transcription and export complex 2 subunit
699048
Mouse
MGI:1919286
223527
Rat
RGD:1596439
685258
Dog
ENY2, transcription and export complex 2 subunit
VGNC:40387
475074
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ENY2, transcription and export complex 2 subunit
Macaque
ENY2, transcription and export complex 2 subunit
Mouse
Rat
Dog
ENY2, transcription and export complex 2 subunit
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NPA8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Protein-Protein Interactions (152)
1 – 10 of 152
ATXN7L3
Tbio
Novelty: 0.1572083
p_int: 0.946631735
p_ni: 0.053368265
Score: 0.997
Data Source: BioPlex,STRINGDB
TADA2B
Tbio
Family: TF
Novelty: 0.06387677
Score: 0.989
Data Source: STRINGDB
SGF29
Tbio
Family: Epigenetic
Novelty: 0.0426456
Score: 0.989
Data Source: STRINGDB
USP22
Tbio
Family: Enzyme
Novelty: 0.01416662
Score: 0.983
Data Source: STRINGDB
SUPT20H
Tbio
Novelty: 0.00625899
Score: 0.981
Data Source: STRINGDB
TADA2A
Tbio
Family: TF
Novelty: 0.07665459
Score: 0.981
Data Source: STRINGDB
MCM3AP
Tbio
Novelty: 0.02025593
Score: 0.978
Data Source: STRINGDB
ATXN7
Tbio
Novelty: 0.00323014
Score: 0.977
Data Source: STRINGDB
KAT2A
Tbio
Family: Epigenetic
Novelty: 0.00238831
Score: 0.973
Data Source: STRINGDB
TRRAP
Tbio
Novelty: 0.01517245
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  130.17

PubMed score by year
PubTator Score  27.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer