Tchem MMP25 Matrix metalloproteinase-25

Protein Summary

Description

May activate progelatinase A. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NPA2
• D3DUA8
• Q9H3Q0
• MMP-25

Gene Name

• MMP25

Ensembl ID

• ENST00000336577
• ENSP00000337816
• ENSG00000008516

Symbol

• MMP20
• MMPL1
• MT6MMP
• MMP20
• MMPL1
• MMP-25
• MMP20A
• MT6MMP
• MTMMP6
• MT-MMP6
• MT6-MMP
• MT-MMP 6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
virus perturbation	0.9
co-expressed gene	0.61
phenotype	0.61
PubMedID	0.61

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Matrix Metalloproteinase-25

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Matrix Metalloproteinase-25

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.27   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.27   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0