MMP25
Matrix metalloproteinase-25
Protein Summary
May activate progelatinase A. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gen ...more
- ENST00000336577
- ENSP00000337816
- ENSG00000008516
- MMP20
- MMPL1
- MT6MMP
- MMP20
- MMPL1
- MMP-25
- MMP20A
- MT6MMP
- MTMMP6
- MT-MMP6
- MT6-MMP
- MT-MMP 6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
virus perturbation | 0.9 | ||
co-expressed gene | 0.61 | ||
phenotype | 0.61 | ||
PubMedID | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.23 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 284 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.23 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 284 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (8)
Protein-Protein Interactions (142)
Nearest Tclin Targets
Pathways (11)
Reactome (6)
KEGG (1)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Immune System | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (3)
Components (6)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
aspartate aminotransferase measurement | 1 | 1 | 1 | 53.7 | |||||
serum alanine aminotransferase measurement | 1 | 1 | 1 | 17.2 | |||||
balding measurement | 1 | 1 | 1 | 13.1 | |||||
sex hormone-binding globulin measurement | 1 | 1 | 1 | 6.6 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
aspartate aminotransferase measurement | 1 | 53.7 | |||||
serum alanine aminotransferase measurement | 1 | 17.2 | |||||
balding measurement | 1 | 13.1 | |||||
sex hormone-binding globulin measurement | 1 | 6.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | matrix metallopeptidase 25 | VGNC:5840 | 749738 | |||||
Macaque | matrix metallopeptidase 25 | 700486 | ||||||
Mouse | MGI:2443938 | 240047 | ||||||
Dog | matrix metallopeptidase 25 | VGNC:43284 | 490046 | |||||
Horse | matrix metallopeptidase 25 | VGNC:20232 | 100068942 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | matrix metallopeptidase 25 | |||||
Macaque | matrix metallopeptidase 25 | |||||
Mouse | ||||||
Dog | matrix metallopeptidase 25 | |||||
Horse | matrix metallopeptidase 25 | |||||
Publication Statistics
PubMed Score 48.23
PubMed score by year
PubTator Score 26.47
PubTator score by year
Related Publications
Text Mined References (29)
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Year | Title |
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