Tchem MMP25 Matrix metalloproteinase-25

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Matrix Metalloproteinase-25

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Matrix Metalloproteinase-25

Protein Summary

Description

May activate progelatinase A. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NPA2
• D3DUA8
• Q9H3Q0
• MMP-25

Gene Name

• MMP25

Ensembl ID

• ENST00000336577
• ENSP00000337816
• ENSG00000008516

Symbol

• MMP20
• MMPL1
• MT6MMP
• MMP20
• MMPL1
• MMP-25
• MMP20A
• MT6MMP
• MTMMP6
• MT-MMP6
• MT6-MMP
• MT-MMP 6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
virus perturbation	0.9
co-expressed gene	0.61
phenotype	0.61
PubMedID	0.61

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.23   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.23   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (8)

Explore Active Ligands

1 – 8 of 8

CGS-27023

MMP25Tchem Enzyme

IC50 : 8.82

CHEMBL1795862

MMP25Tchem Enzyme

IC50 : 8.47

CHEMBL1795351

MMP25Tchem Enzyme

IC50 : 7.47

CHEMBL1795861

MMP25Tchem Enzyme

IC50 : 6.77

CHEMBL1795858

MMP25Tchem Enzyme

IC50 : 6.47

CHEMBL1795859

MMP25Tchem Enzyme

IC50 : 7.12

CHEMBL1795857

MMP25Tchem Enzyme

IC50 : 7.42

CHEMBL1795860

MMP25Tchem Enzyme

IC50 : 6.66

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
aspartate aminotransferase measurement	EFO_0004736	1	1	1		53.7
serum alanine aminotransferase measurement	EFO_0004735	1	1	1		17.2
balding measurement	EFO_0007825	1	1	1		13.1
sex hormone-binding globulin measurement	EFO_0004696	1	1	1		6.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
aspartate aminotransferase measurement	EFO_0004736	1		53.7
serum alanine aminotransferase measurement	EFO_0004735	1		17.2
balding measurement	EFO_0007825	1		13.1
sex hormone-binding globulin measurement	EFO_0004696	1		6.6

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	matrix metallopeptidase 25	VGNC:5840	749738
Macaque	matrix metallopeptidase 25		700486
Mouse	matrix metallopeptidase 25	MGI:2443938	240047
Dog	matrix metallopeptidase 25	VGNC:43284	490046
Horse	matrix metallopeptidase 25	VGNC:20232	100068942

Species	Name	OMA	EggNOG	Inparanoid
Chimp	matrix metallopeptidase 25
Macaque	matrix metallopeptidase 25
Mouse	matrix metallopeptidase 25
Dog	matrix metallopeptidase 25
Horse	matrix metallopeptidase 25

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

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AF-Q9NPA2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)

Reactome (6)

KEGG (1)

PathwayCommons (1)

WikiPathways (3)

Activation of Matrix Metalloproteinases (R-HSA-1592389)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of Matrix Metalloproteinases	33 targets	R-HSA-1592389
Reactome	Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249

Name	Explore in Pharos	Explore in Source
Activation of Matrix Metalloproteinases	33 targets	R-HSA-1592389
Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Extracellular matrix organization	297 targets	R-HSA-1474244
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249

Gene Ontology Terms (13)

Functions (3)

Components (6)

Processes (4)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
metallopeptidase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
metalloendopeptidase activity	Inferred from Electronic Annotation (IEA)	InterPro
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (142)

Explore Interacting Targets

1 – 10 of 142

• See Interactions on String-DB

TIMP2

Tbio

Family:  Enzyme

Novelty:  0.00064016

Score:  0.971

Data Source:  STRINGDB

FURIN

Tchem

Family:  Enzyme

Novelty:  0.00055079

Score:  0.945

Data Source:  STRINGDB

PLAU

Tchem

Family:  Enzyme

Novelty:  0.0005322

Score:  0.942

Data Source:  STRINGDB

ADAM8

Tchem

Family:  Enzyme

Novelty:  0.00871246

Score:  0.93

Data Source:  STRINGDB

ADAM10

Tchem

Family:  Enzyme

Novelty:  0.00160129

Score:  0.927

Data Source:  STRINGDB

ITGB2

Tclin

Novelty:  0.00185859

Score:  0.921

Data Source:  STRINGDB

PLAUR

Tchem

Family:  Enzyme

Novelty:  0.00087642

Score:  0.919

Data Source:  STRINGDB

ITGAM

Tbio

Novelty:  0.00017521

Score:  0.915

Data Source:  STRINGDB

FPR2

Tchem

Family:  GPCR

Novelty:  0.00228744

Score:  0.913

Data Source:  STRINGDB

CEACAM3

Tbio

Novelty:  0.02597577

Score:  0.912

Data Source:  STRINGDB

Publication Statistics

PubMed Score  48.23

PubMed score by year

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PubTator Score  26.47

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Calcium
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Extracellular matrix
Glycoprotein
GPI-anchor
Hydrolase
Lipoprotein

GWAS Trait Find Similar Targets

No Header	No Header
aspartate aminotransferase measurement
balding measurement
serum alanine aminotransferase measurement
sex hormone-binding globulin measurement