MMP25
Matrix metalloproteinase-25
Protein Classes
Protein Summary
May activate progelatinase A. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gen ...more
- ENST00000336577
- ENSP00000337816
- ENSG00000008516
- MMP20
- MMPL1
- MT6MMP
- MMP20
- MMPL1
- MMP-25
- MMP20A
- MT6MMP
- MTMMP6
- MT-MMP6
- MT6-MMP
- MT-MMP 6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
virus perturbation | 0.9 | ||
co-expressed gene | 0.61 | ||
phenotype | 0.61 | ||
PubMedID | 0.61 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.94 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 284 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.94 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 284 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (8)
1 – 8 of 8
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 1 | 1 | 1 | 7.2 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 1 | 7.2 | |||||
Pathways (11)
Reactome (6)
KEGG (1)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Immune System | ||||
Innate Immune System | ||||
Gene Ontology Terms (13)
Functions (3)
Components (6)
Processes (4)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (142)
1 – 10 of 142
TIMP2
Family: Enzyme
Novelty: 0.00064016
Score: 0.971
Data Source: STRINGDB
FURIN
Family: Enzyme
Novelty: 0.00055079
Score: 0.945
Data Source: STRINGDB
PLAU
Family: Enzyme
Novelty: 0.0005322
Score: 0.942
Data Source: STRINGDB
ADAM8
Family: Enzyme
Novelty: 0.00871246
Score: 0.93
Data Source: STRINGDB
ADAM10
Family: Enzyme
Novelty: 0.00160129
Score: 0.927
Data Source: STRINGDB
ITGB2
Novelty: 0.00185859
Score: 0.921
Data Source: STRINGDB
PLAUR
Family: Enzyme
Novelty: 0.00087642
Score: 0.919
Data Source: STRINGDB
ITGAM
Novelty: 0.00017521
Score: 0.915
Data Source: STRINGDB
FPR2
Family: GPCR
Novelty: 0.00228744
Score: 0.913
Data Source: STRINGDB
CEACAM3
Novelty: 0.02597577
Score: 0.912
Data Source: STRINGDB
Publication Statistics
PubMed Score 46.94
PubMed score by year
PubTator Score 26.47
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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