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Tchem
MMP25
Matrix metalloproteinase-25

Protein Summary
Description
May activate progelatinase A. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336577
  • ENSP00000337816
  • ENSG00000008516

Symbol
  • MMP20
  • MMPL1
  • MT6MMP
  • MMP20
  • MMPL1
  • MMP-25
  • MMP20A
  • MT6MMP
  • MTMMP6
  • MT-MMP6
  • MT6-MMP
  • MT-MMP 6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.9
co-expressed gene
0.61
phenotype
0.61
PubMedID
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.94   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.94   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
7.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
7.2
Pathways (11)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Degradation of the extracellular matrix
Extracellular matrix organization
Immune System
Innate Immune System
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (142)
1 – 10 of 142
TIMP2
Tbio
Family: Enzyme
Novelty: 0.00064016
Score: 0.971
Data Source: STRINGDB
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
Score: 0.945
Data Source: STRINGDB
PLAU
Tchem
Family: Enzyme
Novelty: 0.0005322
Score: 0.942
Data Source: STRINGDB
ADAM8
Tchem
Family: Enzyme
Novelty: 0.00871246
Score: 0.93
Data Source: STRINGDB
ADAM10
Tchem
Family: Enzyme
Novelty: 0.00160129
Score: 0.927
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.921
Data Source: STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
Score: 0.919
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.915
Data Source: STRINGDB
FPR2
Tchem
Family: GPCR
Novelty: 0.00228744
Score: 0.913
Data Source: STRINGDB
CEACAM3
Tbio
Novelty: 0.02597577
Score: 0.912
Data Source: STRINGDB
Publication Statistics
PubMed Score  46.94

PubMed score by year
PubTator Score  26.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer