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Tbio
KCNMB3
Calcium-activated potassium channel subunit beta-3

Protein Classes
Protein Summary
Description
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314235
  • ENSP00000319370
  • ENSG00000171121
  • ENST00000349697
  • ENSP00000327866
  • ENST00000392685
  • ENSP00000376451
  • ENST00000392686
  • ENSP00000376452
  • ENST00000485523
  • ENSP00000418536
  • ENST00000497599
  • ENSP00000417091

Symbol
  • KCNMB2
  • KCNMBL
  • HBETA3
  • KCNMB2
  • KCNMBL
  • BKBETA3
  • SLOBETA3
  • SLO-BETA-3
  • K(VCA)BETA-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
cell type or tissue
0.62
small molecule perturbation
0.57
tissue
0.57
transcription factor
0.52


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.49   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.49   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily M regulatory beta subunit 3
VGNC:1857
745901
Macaque
potassium calcium-activated channel subfamily M regulatory beta subunit 3
709856
Mouse
MGI:3612244
100502876
Rat
RGD:1311852
310303
Dog
potassium calcium-activated channel subfamily M regulatory beta subunit 3
VGNC:42283
488085
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily M regulatory beta subunit 3
Macaque
potassium calcium-activated channel subfamily M regulatory beta subunit 3
Mouse
Rat
Dog
potassium calcium-activated channel subfamily M regulatory beta subunit 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NPA1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Ca2+ activated K+ channels (R-HSA-1296052)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ca2+ activated K+ channels
Reactome
Hemostasis
Reactome
Neuronal System
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
Ca2+ activated K+ channels
Hemostasis
Neuronal System
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
Protein-Protein Interactions (36)
1 – 10 of 36
KCNMA1
Tclin
Family: IC
Novelty: 0.00088182
Score: 0.986
Data Source: Reactome,STRINGDB
PRKG2
Tchem
Family: Kinase
Novelty: 0.0138455
Score: 0.912
Data Source: Reactome,STRINGDB
KCNN4
Tchem
Family: IC
Novelty: 0.00244935
Score: 0.85
Data Source: STRINGDB
KCNN3
Tchem
Family: IC
Novelty: 0.00227544
Score: 0.846
Data Source: STRINGDB
KCNMB1
Tbio
Family: IC
Novelty: 0.00736653
Score: 0.832
Data Source: Reactome,STRINGDB
KCNN1
Tchem
Family: IC
Novelty: 0.04266994
Score: 0.827
Data Source: STRINGDB
KCNU1
Tbio
Family: IC
Novelty: 0.02284336
Score: 0.822
Data Source: STRINGDB
KCNMB4
Tbio
Family: IC
Novelty: 0.05362954
Score: 0.821
Data Source: Reactome,STRINGDB
KCNN2
Tchem
Family: IC
Novelty: 0.01865346
Score: 0.812
Data Source: STRINGDB
KCNMB2
Tbio
Family: IC
Novelty: 0.4425394
Score: 0.812
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  9.49

PubMed score by year
PubTator Score  21.32

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer