Tbio TREM1 Triggering receptor expressed on myeloid cells 1

Protein Summary

Description

Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q9NP99
• B4DWG2
• K7EJW1
• Q53FL8
• Q5T2C9
• Q86YU1
• TREM-1

Gene Name

• TREM1

Ensembl ID

• ENST00000244709
• ENSP00000244709
• ENSG00000124731
• ENST00000334475
• ENSP00000334284
• ENST00000591620
• ENSP00000465345

Symbol

• CD354
• TREM-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
biological term	0.79
biological process	0.71
cell type or tissue	0.71
microRNA	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 556.55   (req: < 5)

Gene RIFs: 234   (req: <= 3)

Antibodies: 648   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 556.55   (req: >= 5)

Gene RIFs: 234   (req: > 3)

Antibodies: 648   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0