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Tbio
TREM1
Triggering receptor expressed on myeloid cells 1

Protein Summary
Description
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244709
  • ENSP00000244709
  • ENSG00000124731
  • ENST00000334475
  • ENSP00000334284
  • ENST00000591620
  • ENSP00000465345

Symbol
  • CD354
  • TREM-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
biological term
0.79
biological process
0.71
cell type or tissue
0.71
microRNA
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.97   (req: < 5)
Gene RIFs: 152   (req: <= 3)
Antibodies: 648   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.97   (req: >= 5)
Gene RIFs: 152   (req: > 3)
Antibodies: 648   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
triggering receptor expressed on myeloid cells 1
693558
Mouse
MGI:1930005
58217
Rat
RGD:1309467
301229
Dog
triggering receptor expressed on myeloid cells 1
VGNC:47793
608994
Horse
triggering receptor expressed on myeloid cells 1
VGNC:24481
100054285
Species
Name
OMA
EggNOG
Inparanoid
Macaque
triggering receptor expressed on myeloid cells 1
Mouse
Rat
Dog
triggering receptor expressed on myeloid cells 1
Horse
triggering receptor expressed on myeloid cells 1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (211)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cell surface interactions at the vascular wall
Reactome
DAP12 interactions
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cell surface interactions at the vascular wall
DAP12 interactions
Hemostasis
Immune System
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (107)
1 – 10 of 107
TYROBP
Tbio
Family: Enzyme
Novelty: 0.00410031
Score: 0.989
Data Source: Reactome,STRINGDB
TREM2
Tbio
Novelty: 0.00228007
Score: 0.918
Data Source: STRINGDB
TREML2
Tbio
Novelty: 0.05038302
Score: 0.901
Data Source: STRINGDB
TREML1
Tbio
Novelty: 0.03513416
Score: 0.805
Data Source: STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.783
Data Source: STRINGDB
FPR1
Tchem
Family: GPCR
Novelty: 0.00256884
Score: 0.783
Data Source: STRINGDB
TLR2
Tchem
Novelty: 0.00023242
Score: 0.721
Data Source: STRINGDB
CLEC5A
Tbio
Novelty: 0.01710591
Score: 0.696
Data Source: STRINGDB
IL1B
Tclin
Novelty: 0.0000308
Score: 0.679
Data Source: STRINGDB
TLR8
Tchem
Novelty: 0.0023384
Score: 0.676
Data Source: STRINGDB
Publication Statistics
PubMed Score  486.97

PubMed score by year
PubTator Score  244.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer