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Tbio
MYOZ1
Myozenin-1

Protein Summary
Description
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359322
  • ENSP00000352272
  • ENSG00000177791

Symbol
  • MYOZ
  • CS-2
  • FATZ
  • MYOZ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.54
tissue sample
0.51
cellular component
0.48
cell line
0.44
chemical
0.44


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.24   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.24   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myozenin 1
VGNC:4959
737238
Macaque
myozenin 1
706768
Mouse
MGI:1929471
59011
Rat
RGD:1561064
498440
Dog
myozenin 1
VGNC:43583
479250
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myozenin 1
Macaque
myozenin 1
Mouse
Rat
Dog
myozenin 1
Protein-Protein Interactions (83)
1 – 10 of 83
LDB3
Tbio
Novelty: 0.01178009
Score: 0.85
Data Source: STRINGDB
ATP2A1
Tchem
Family: Transporter
Novelty: 0.00355092
Score: 0.843
Data Source: STRINGDB
ACTN2
Tbio
Novelty: 0.00615882
Score: 0.816
Data Source: STRINGDB
CASQ1
Tbio
Novelty: 0.00815945
Score: 0.814
Data Source: STRINGDB
TCAP
Tbio
Novelty: 0.00623581
Score: 0.813
Data Source: STRINGDB
ACTN1
Tbio
Novelty: 0.00654004
Score: 0.791
Data Source: STRINGDB
ACTN3
Tbio
Novelty: 0.00375035
Score: 0.785
Data Source: STRINGDB
MYOT
Tbio
Novelty: 0.00888671
Score: 0.775
Data Source: STRINGDB
TNNT3
Tbio
Novelty: 0.0212335
Score: 0.775
Data Source: STRINGDB
FLNC
Tbio
Novelty: 0.00463205
Score: 0.772
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.24

PubMed score by year
PubTator Score  13.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer