Tbio MYOZ1 Myozenin-1

Protein Summary

Description

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q9NP98
• Q9H1I7

Gene Name

• MYOZ1

Ensembl ID

• ENST00000359322
• ENSP00000352272
• ENSG00000177791

Symbol

• MYOZ
• CS-2
• FATZ
• MYOZ

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.54
tissue sample	0.51
cellular component	0.48
cell line	0.44
chemical	0.44

Protein Classes

PANTHER Classes

Protein / Structural Protein / Myozenin-1

DTO Classes

Protein / Cellular Structure / Myozenin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.36   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 230   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.36   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0