Tbio DYNLRB1 Dynein light chain roadblock-type 1

Protein Summary

Description

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q9NP97
• B1AKR5
• Q5TC72
• Q96IV3
• Q9NQM2

Gene Name

• DYNLRB1

Ensembl ID

• ENST00000300469
• ENSP00000300469
• ENSG00000125971
• ENST00000357156
• ENSP00000349679

Symbol

• BITH
• DNCL2A
• DNLC2A
• ROBLD1
• BLP
• BITH
• DNCL2A
• DNLC2A
• ROBLD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.99
interacting protein	0.91
histone modification site profile	0.88
tissue	0.77

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Dynein Light Chain Roadblock-type 1

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Dynein Light Chain Roadblock-type 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.67   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.67   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0