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Tbio
SLC39A2
Zinc transporter ZIP2

Protein Summary
Description
Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis. This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298681
  • ENSP00000298681
  • ENSG00000165794
  • ENST00000554422
  • ENSP00000452568

Symbol
  • ZIP2
  • 6A1
  • ZIP2
  • ETI-1
  • ZIP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.58
tissue
0.58
gene perturbation
0.49
cell line
0.45
chemical
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.74   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.74   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
SLC39A7
Tbio
Family:  Transporter
Novelty:  0.01746862
Score:  0.875
Data Source:  STRINGDB
SLC39A11
Tbio
Family:  Transporter
Novelty:  0.09770302
Score:  0.871
Data Source:  STRINGDB
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
Score:  0.865
Data Source:  STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
Score:  0.817
Data Source:  STRINGDB
SLC39A14
Tbio
Family:  Transporter
Novelty:  0.01053215
Score:  0.813
Data Source:  STRINGDB
SLC39A6
Tbio
Family:  Transporter
Novelty:  0.0144314
Score:  0.798
Data Source:  STRINGDB
SLC30A4
Tbio
Family:  Transporter
Novelty:  0.02209
Score:  0.793
Data Source:  STRINGDB
SLC30A1
Tbio
Family:  Transporter
Novelty:  0.00528427
Score:  0.79
Data Source:  STRINGDB
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
Score:  0.786
Data Source:  STRINGDB
SLC39A8
Tbio
Family:  Transporter
Novelty:  0.00923197
Score:  0.786
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Metal ion SLC transporters (R-HSA-425410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metal ion SLC transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Reactome
Zinc influx into cells by the SLC39 gene family
Name
Explore in Pharos
Explore in Source
Metal ion SLC transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Zinc influx into cells by the SLC39 gene family
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
1
3
77.1
testosterone measurement
2
1
2
76.3
hemoglobin measurement
2
1
2
74.8
red blood cell density measurement
1
1
1
69.4
platelet crit
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
77.1
testosterone measurement
2
76.3
hemoglobin measurement
2
74.8
red blood cell density measurement
1
69.4
platelet crit
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 2
VGNC:8211
465210
Mouse
MGI:2684326
214922
Rat
RGD:1306291
305846
Dog
solute carrier family 39 member 2
VGNC:46403
482564
Horse
solute carrier family 39 member 2
VGNC:23203
100072701
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 2
Mouse
Rat
Dog
solute carrier family 39 member 2
Horse
solute carrier family 39 member 2
Publication Statistics
PubMed Score 51.74
PubMed score by year
PubTator Score 33.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title