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Tbio
MRPS30
39S ribosomal protein S30, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000507110
  • ENSP00000424328
  • ENSG00000112996

Symbol
  • PDCD9
  • PAP
  • PDCD9
  • S30mt
  • MRP-S30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.84
transcription factor perturbation
0.8
transcription factor
0.77
histone modification site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.48   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.48   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
25.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
25.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S30
VGNC:4090
461887
Macaque
mitochondrial ribosomal protein S30
701699
Mouse
MGI:1926237
59054
Rat
RGD:1309697
294767
Dog
mitochondrial ribosomal protein S30
VGNC:43420
479341
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S30
Macaque
mitochondrial ribosomal protein S30
Mouse
Rat
Dog
mitochondrial ribosomal protein S30
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NP92-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (157)
1 – 10 of 157
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.999999977
p_ni: 2.3e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.999999943
p_ni: 5.7e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL42
Tbio
Novelty: 0.48241447
p_int: 0.999999531
p_ni: 4.69e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL28
Tdark
Novelty: 0.23845162
p_int: 0.999999096
p_ni: 9.04e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL41
Tbio
Novelty: 0.04024303
p_int: 0.99999621
p_ni: 0.00000379
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPL45
Tdark
Novelty: 0.42464896
p_int: 0.999987816
p_ni: 0.000012184
Score: 0.994
Data Source: BioPlex,STRINGDB
MRPL39
Tbio
Novelty: 0.14346457
p_int: 0.999977237
p_ni: 0.000022763
Score: 0.984
Data Source: BioPlex,STRINGDB
MRPL40
Tbio
Novelty: 0.09916967
p_int: 0.999977076
p_ni: 0.000022924
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.999972766
p_ni: 0.000027234
Score: 0.992
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.48

PubMed score by year
PubTator Score  14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer