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Tbio
SLC6A20
Sodium- and chloride-dependent transporter XTRP3

Protein Summary
Description
Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Involved in the transport of glycine. Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353278
  • ENSP00000296133
  • ENSG00000163817
  • ENST00000358525
  • ENSP00000346298

Symbol
  • SIT1
  • XT3
  • XTRP3
  • XT3
  • SIT1
  • Xtrp3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.84
molecular function
0.84
histone modification site profile
0.72
cell line
0.6
microRNA
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.56   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.56   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
ATP8A1
Tbio
Family:  Transporter
Novelty:  0.02003643
p_int:  0.999999992
p_ni:  8e-9
Data Source:  BioPlex
TEX2
Tbio
Novelty:  0.07679544
p_int:  0.999999224
p_ni:  7.25e-7
p_wrong:  5e-8
Data Source:  BioPlex
ACSF2
Tbio
Family:  Enzyme
Novelty:  0.10280059
p_int:  0.999843517
p_ni:  0.000156482
p_wrong:  2e-9
Data Source:  BioPlex
TLCD2
Tdark
Novelty:  0.42814411
p_int:  0.997808914
p_ni:  0.002168196
p_wrong:  0.00002289
Data Source:  BioPlex
TMEM242
Tdark
Novelty:  0.99055845
p_int:  0.990124028
p_ni:  0.000250436
p_wrong:  0.009625536
Data Source:  BioPlex
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.987291276
p_ni:  0.012703367
p_wrong:  0.000005357
Data Source:  BioPlex
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.967763781
p_ni:  0.032234209
p_wrong:  0.00000201
Data Source:  BioPlex
FITM2
Tdark
Novelty:  0.01882177
p_int:  0.956476345
p_ni:  0.043081103
p_wrong:  0.000442552
Data Source:  BioPlex
GPR89A
Tbio
Family:  IC
Novelty:  0.06782776
p_int:  0.952753719
p_ni:  0.047123219
p_wrong:  0.000123062
Data Source:  BioPlex
LPCAT3
Tbio
Family:  Enzyme
Novelty:  0.00485213
p_int:  0.931733666
p_ni:  0.067118149
p_wrong:  0.001148186
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Disease
Disorders of transmembrane transporters
Na+/Cl- dependent neurotransmitter transporters
SLC transporter disorders
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
2
3
91.1
COVID-19
2
2
0
1.8
88.4
ganglion cell inner plexiform layer thickness measurement
1
1
1
76
blood protein measurement
1
1
1
71.6
alkaline phosphatase measurement
1
1
1
67.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
91.1
COVID-19
0
1.8
88.4
ganglion cell inner plexiform layer thickness measurement
1
76
blood protein measurement
1
71.6
alkaline phosphatase measurement
1
67.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 20
VGNC:12189
460318
Macaque
solute carrier family 6 member 20
714045
Mouse
MGI:2143217
102680
Rat
RGD:621651
113918
Dog
solute carrier family 6 member 20
VGNC:46463
484794
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 20
Macaque
solute carrier family 6 member 20
Mouse
Rat
Dog
solute carrier family 6 member 20
Publication Statistics
PubMed Score 61.56
PubMed score by year
PubTator Score 13.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title