SLC6A20
Sodium- and chloride-dependent transporter XTRP3
Protein Summary
Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Involved in the transport of glycine. Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008]
- ENST00000353278
- ENSP00000296133
- ENSG00000163817
- ENST00000358525
- ENSP00000346298
- SIT1
- XT3
- XTRP3
- XT3
- SIT1
- Xtrp3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.84 | ||
molecular function | 0.84 | ||
histone modification site profile | 0.72 | ||
cell line | 0.6 | ||
microRNA | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.24 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 21 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.24 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 21 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0