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Tbio
POLM
DNA-directed DNA/RNA polymerase mu

Protein Summary
Description
Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242248
  • ENSP00000242248
  • ENSG00000122678
  • ENST00000335195
  • ENSP00000335141
  • ENST00000395831
  • ENSP00000379174

Symbol
  • polmu
  • Tdt-N
  • Pol Mu
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.74
histone modification site profile
0.74
tissue sample
0.74
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.25   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.25   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
CTU2
Tdark
Novelty:  0.00936441
p_int:  0.920836162
p_ni:  0.079163838
Score:  0.204
Data Source:  BioPlex,STRINGDB
ACAD8
Tbio
Family:  Enzyme
Novelty:  0.05735881
p_int:  0.807032676
p_ni:  0.192967323
Score:  0.403
Data Source:  BioPlex,STRINGDB
LIG4
Tbio
Family:  Enzyme
Novelty:  0.00412993
Score:  0.972
Data Source:  Reactome,STRINGDB
XRCC4
Tbio
Novelty:  0.00305644
Score:  0.965
Data Source:  Reactome,STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
Score:  0.96
Data Source:  Reactome,STRINGDB
XRCC5
Tbio
Novelty:  0.00150735
Score:  0.95
Data Source:  Reactome,STRINGDB
NHEJ1
Tbio
Novelty:  0.00773499
Score:  0.94
Data Source:  Reactome,STRINGDB
POLL
Tbio
Family:  Enzyme
Novelty:  0.00244645
Score:  0.936
Data Source:  STRINGDB
PRKDC
Tchem
Family:  Kinase
Novelty:  0.00107984
Score:  0.934
Data Source:  Reactome,STRINGDB
DCLRE1C
Tbio
Novelty:  0.01064408
Score:  0.922
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Nonhomologous End-Joining (NHEJ)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Nonhomologous End-Joining (NHEJ)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
3
3
91.6
glucose measurement
1
2
2
90.1
triglyceride measurement
4
4
4
88.8
fasting blood glucose measurement
2
3
3
80.7
sex hormone-binding globulin measurement
3
1
3
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
91.6
glucose measurement
2
90.1
triglyceride measurement
4
88.8
fasting blood glucose measurement
3
80.7
sex hormone-binding globulin measurement
3
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase mu
VGNC:8737
737708
Mouse
MGI:1860191
54125
Rat
RGD:1308247
289757
Horse
DNA polymerase mu
VGNC:21665
100051774
Cow
DNA polymerase mu
VGNC:33128
513780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase mu
Mouse
Rat
Horse
DNA polymerase mu
Cow
DNA polymerase mu
Publication Statistics
PubMed Score 301.25
PubMed score by year
PubTator Score 60.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title