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Tbio
POLM
DNA-directed DNA/RNA polymerase mu

Protein Summary
Description
Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242248
  • ENSP00000242248
  • ENSG00000122678
  • ENST00000335195
  • ENSP00000335141
  • ENST00000395831
  • ENSP00000379174

Symbol
  • polmu
  • Tdt-N
  • Pol Mu
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.74
histone modification site profile
0.74
tissue sample
0.74
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.6   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.6   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0