Tbio TNFRSF12A Tumor necrosis factor receptor superfamily member 12A

Protein Summary

Description

Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Uniprot Accession IDs

• Q9NP84
• D3DUA6
• Q9HCS0

Gene Name

• TNFRSF12A

Ensembl ID

• ENST00000326577
• ENSP00000326737
• ENSG00000006327
• ENST00000341627
• ENSP00000343894

Symbol

• FN14
• FN14
• CD266
• TWEAKR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
transcription factor binding site profile	0.89
small molecule perturbation	0.85
transcription factor perturbation	0.8
PubMedID	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.42   (req: < 5)

Gene RIFs: 119   (req: <= 3)

Antibodies: 510   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.42   (req: >= 5)

Gene RIFs: 119   (req: > 3)

Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0