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Tbio
TNFRSF12A
Tumor necrosis factor receptor superfamily member 12A

Protein Summary
Description
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326577
  • ENSP00000326737
  • ENSG00000006327
  • ENST00000341627
  • ENSP00000343894

Symbol
  • FN14
  • FN14
  • CD266
  • TWEAKR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
transcription factor binding site profile
0.89
small molecule perturbation
0.85
transcription factor perturbation
0.8
PubMedID
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.88   (req: < 5)
Gene RIFs: 96   (req: <= 3)
Antibodies: 510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.88   (req: >= 5)
Gene RIFs: 96   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 12A
VGNC:5943
107968771
Mouse
MGI:1351484
27279
Rat
RGD:631329
302965
Dog
TNF receptor superfamily member 12A
VGNC:47656
610734
Horse
TNF receptor superfamily member 12A
VGNC:24365
100146755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 12A
Mouse
Rat
Dog
TNF receptor superfamily member 12A
Horse
TNF receptor superfamily member 12A
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NP84-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (263)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Reactome
TNFR2 non-canonical NF-kB pathway
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFR2 non-canonical NF-kB pathway
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (110)
1 – 10 of 110
TNFSF12
Tbio
Novelty: 0.00298471
Score: 0.995
Data Source: Reactome,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.962
Data Source: Reactome,STRINGDB
BIRC2
Tchem
Novelty: 0.00199701
Score: 0.958
Data Source: Reactome,STRINGDB
TRAF3
Tbio
Novelty: 0.0022525
Score: 0.955
Data Source: Reactome,STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.954
Data Source: STRINGDB
TNFRSF1B
Tbio
Novelty: 0.0013033
Score: 0.939
Data Source: STRINGDB
TNFRSF13C
Tbio
Novelty: 0.00198038
Score: 0.939
Data Source: STRINGDB
TNFSF13B
Tclin
Novelty: 0.00069885
Score: 0.937
Data Source: STRINGDB
LTBR
Tbio
Novelty: 0.003823
Score: 0.937
Data Source: STRINGDB
BIRC3
Tchem
Novelty: 0.00189613
Score: 0.927
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  239.88

PubMed score by year
PubTator Score  158.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer