Tbio SARS2 Serine--tRNA ligase, mitochondrial

Protein Summary

Description

Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q9NP81
• A6NHW7
• B4DE10
• Q9BVP3

Gene Name

• SARS2

Ensembl ID

• ENST00000221431
• ENSP00000221431
• ENSG00000104835
• ENST00000600042
• ENSP00000472847
• ENST00000634687
• ENSP00000489539
• ENSG00000283104
• ENST00000635245
• ENSP00000489453

Symbol

• SARSM
• SYS
• SARS
• SERS
• SARSM
• SerRS
• SerRSmt
• mtSerRS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.94
molecular function	0.93
protein domain	0.73
transcription factor binding site profile	0.72
tissue	0.7

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Serine--trna Ligase, Mitochondrial

Protein / Ligase / Aminoacyl-trna Synthetase / Serine--trna Ligase, Mitochondrial

DTO Classes

Protein / Enzyme / Ligase / Aminoacyl-trna Synthetase / Serine--trna Ligase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.52   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 124   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.52   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0