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Tbio
PNPLA8
Calcium-independent phospholipase A2-gamma

Protein Summary
Description
Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257694
  • ENSP00000257694
  • ENSG00000135241
  • ENST00000422087
  • ENSP00000410804
  • ENST00000426128
  • ENSP00000394988
  • ENST00000436062
  • ENSP00000406779
  • ENST00000453144
  • ENSP00000387789

Symbol
  • IPLA22
  • IPLA2G
  • MMLA
  • IPLA2G
  • IPLA2-2
  • iPLA2gamma
  • PNPLA-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
transcription factor perturbation
0.8
virus perturbation
0.79
kinase perturbation
0.76
tissue sample
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.27   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.27   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 8
VGNC:4472
472484
Macaque
patatin like phospholipase domain containing 8
700851
Mouse
MGI:1914702
67452
Rat
RGD:1311444
314075
Dog
patatin like phospholipase domain containing 8
VGNC:44758
475880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 8
Macaque
patatin like phospholipase domain containing 8
Mouse
Rat
Dog
patatin like phospholipase domain containing 8
Pathways (23)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Protein-Protein Interactions (33)
1 – 10 of 33
PNPLA2
Tchem
Family: Enzyme
Novelty: 0.00149181
Score: 0.841
Data Source: STRINGDB
ERICH1
Tdark
Novelty: 1.30496362
Score: 0.732
Data Source: STRINGDB
PNPLA6
Tbio
Family: Enzyme
Novelty: 0.00295195
Score: 0.699
Data Source: STRINGDB
PNPLA3
Tbio
Family: Enzyme
Novelty: 0.00180327
Score: 0.674
Data Source: STRINGDB
TMPO
Tbio
Novelty: 0.00715046
Score: 0.667
Data Source: STRINGDB
TMEM131
Tdark
Novelty: 0.02152783
Score: 0.667
Data Source: STRINGDB
TMPO
Tbio
Novelty: 0.00715046
Score: 0.667
Data Source: STRINGDB
PNPLA7
Tdark
Family: Enzyme
Novelty: 0.11025485
Score: 0.64
Data Source: STRINGDB
PNPLA4
Tbio
Family: Enzyme
Novelty: 0.07471752
Score: 0.629
Data Source: STRINGDB
PNPLA5
Tdark
Family: Enzyme
Novelty: 0.22301215
Score: 0.556
Data Source: STRINGDB
Publication Statistics
PubMed Score  46.27

PubMed score by year
PubTator Score  16.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer