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Tbio
VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

Protein Summary
Description
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding. C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 [PubMed 15644320]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367630
  • ENSP00000356602
  • ENSG00000009844
  • ENST00000452973
  • ENSP00000395767

Symbol
  • C6orf55
  • DRG1
  • LIP5
  • SBP1
  • DRG-1
  • My012
  • C6orf55
  • HSPC228
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
disease perturbation
0.98
hub protein
0.98
transcription factor binding site profile
0.9
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.69   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.69   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
6
7
94.7
FEV/FEC ratio
1
1
1
32.7
forced expiratory volume
1
1
1
29.9
peak expiratory flow
1
1
1
24.3
1
1
0
1.1
11
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
7
94.7
FEV/FEC ratio
1
32.7
forced expiratory volume
1
29.9
peak expiratory flow
1
24.3
0
1.1
11
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vesicle trafficking 1
VGNC:10019
463033
Macaque
vesicle trafficking 1
701578
Mouse
MGI:1913451
66201
Rat
RGD:1305031
292640
Dog
vesicle trafficking 1
VGNC:48314
612830
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vesicle trafficking 1
Macaque
vesicle trafficking 1
Mouse
Rat
Dog
vesicle trafficking 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NP79-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Budding and maturation of HIV virion (R-HSA-162588)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Budding and maturation of HIV virion
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
HIV Infection
HIV Life Cycle
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (103)
1 – 10 of 103
CHMP5
Tbio
Novelty:  0.03378716
p_int:  0.999999994
p_ni:  6e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
p_int:  0.999863822
p_ni:  0.000136178
Score:  0.997
Data Source:  BioPlex,STRINGDB
STMN4
Tbio
Novelty:  0.00422625
p_int:  0.998913667
p_ni:  0.001086333
Score:  0.558
Data Source:  BioPlex,STRINGDB
TEAD4
Tchem
Family:  TF
Novelty:  0.0114979
p_int:  0.900312858
p_ni:  0.099687142
Score:  0.189
Data Source:  BioPlex,STRINGDB
VPS4B
Tchem
Novelty:  0.00788708
p_int:  0.839486604
p_ni:  0.160513396
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SPAST
Tbio
Novelty:  0.00303236
p_int:  0.830901111
p_ni:  0.169023205
p_wrong:  0.000075684
Score:  0.906
Data Source:  BioPlex,STRINGDB
VPS4A
Tbio
Novelty:  0.01508121
p_int:  0.826061018
p_ni:  0.173897874
p_wrong:  0.000041108
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.81876344
p_ni:  0.181161983
p_wrong:  0.000074577
Score:  0.196
Data Source:  BioPlex,STRINGDB
ABCG2
Tchem
Family:  Transporter
Novelty:  0.00029779
p_int:  0.766115775
p_ni:  0.23384155
p_wrong:  0.000042675
Data Source:  BioPlex
CHMP1B
Tbio
Novelty:  0.06982523
Score:  0.996
Data Source:  STRINGDB
Publication Statistics
PubMed Score  67.69

PubMed score by year
PubTator Score  18.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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