Tbio VTA1 Vacuolar protein sorting-associated protein VTA1 homolog

Protein Summary

Description

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding. C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 [PubMed 15644320]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9NP79
• B4DW55
• E1P594
• E7ETQ7
• Q5TGM1
• Q6IAE8
• Q9H0R2
• Q9H3K9
• Q9P0Q0

Gene Name

• VTA1

Ensembl ID

• ENST00000367630
• ENSP00000356602
• ENSG00000009844
• ENST00000452973
• ENSP00000395767

Symbol

• C6orf55
• DRG1
• LIP5
• SBP1
• DRG-1
• My012
• C6orf55
• HSPC228

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
disease perturbation	0.98
hub protein	0.98
transcription factor binding site profile	0.9
transcription factor perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.71   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 117   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.71   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0