Tbio ABCB9 ATP-binding cassette sub-family B member 9

Protein Summary

Description

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• Q9NP78
• B4E2J0
• Q5W9G7
• Q769F3
• Q769F4
• Q96AB1
• Q9P208

Gene Name

• ABCB9

Ensembl ID

• ENST00000280560
• ENSP00000280560
• ENSG00000150967
• ENST00000344275
• ENSP00000456813
• ENST00000346530
• ENSP00000280559
• ENST00000392439
• ENSP00000376234
• ENST00000442833
• ENSP00000456375
• ENST00000540285
• ENSP00000441734
• ENST00000542678
• ENSP00000440288

Symbol

• KIAA1520
• TAPL
• EST122234

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
co-expressed gene	0.91
cellular component	0.86
protein domain	0.85
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Atp-binding Cassette Sub-family B Member 9

Protein / ... / Cysteine Protease / Atp-binding Cassette Sub-family B Member 9

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcb Subfamily / Atp-binding Cassette Sub-family B Member 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.21   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 225   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.21   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (43)

Explore Interacting Targets

1 – 10 of 43

• See Interactions on String-DB

SLC17A2

Tdark

Family:  Transporter

Novelty:  0.23941275

p_int:  0.999563201

p_ni:  0.00043626

p_wrong:  5.38e-7

Score:  0.159

Data Source:  BioPlex,STRINGDB

CNGA3

Tchem

Family:  IC

Novelty:  0.00818181

p_int:  0.998740651

p_ni:  0.001259318

p_wrong:  3.1e-8

Data Source:  BioPlex

LRRC8B

Tbio

Novelty:  0.16457267

p_int:  0.996862246

p_ni:  0.003137709

p_wrong:  4.5e-8

Score:  0.183

Data Source:  BioPlex,STRINGDB

TMEM9B

Tdark

Novelty:  0.56628366

p_int:  0.996579952

p_ni:  0.003342134

p_wrong:  0.000077914

Data Source:  BioPlex

RXFP1

Tchem

Family:  GPCR

Novelty:  0.00580827

p_int:  0.994968163

p_ni:  0.005029168

p_wrong:  0.000002669

Data Source:  BioPlex

GRIN2A

Tclin

Family:  IC

Novelty:  0.00060035

p_int:  0.99401809

p_ni:  0.005981559

p_wrong:  3.51e-7

Data Source:  BioPlex

PIK3CA

Tclin

Family:  Kinase

Novelty:  0.00044273

p_int:  0.993960824

p_ni:  0.006037693

p_wrong:  0.000001484

Data Source:  BioPlex

PCDHAC1

Tdark

Novelty:  0.3734734

p_int:  0.993215982

p_ni:  0.006755472

p_wrong:  0.000028546

Score:  0.201

Data Source:  BioPlex,STRINGDB

PCDHA3

Tdark

Novelty:  0.8622898

p_int:  0.977700001

p_ni:  0.022278096

p_wrong:  0.000021903

Score:  0.154

Data Source:  BioPlex,STRINGDB

C3AR1

Tchem

Family:  GPCR

Novelty:  0.00527301

p_int:  0.970066778

p_ni:  0.028432366

p_wrong:  0.001500856

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (2)

KEGG (2)

ABC-family proteins mediated transport (R-HSA-382556)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ABC-family proteins mediated transport	104 targets	R-HSA-382556
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
ABC-family proteins mediated transport	104 targets	R-HSA-382556
Transport of small molecules	725 targets	R-HSA-382551

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (6)

Components (5)

Processes (3)

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1 – 6 of 6

GO Term	Evidence	Assigned by
ATP binding	Inferred from Direct Assay (IDA)	UniProtKB
peptide-transporting ATPase activity	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
ATPase activity, coupled to transmembrane movement of substances	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
oligopeptide-transporting ATPase activity	Traceable Author Statement (TAS)	Reactome

Disease Associations (null)

No disease associations found

GWAS Traits (20)

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1 – 5 of 20

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	3	14	15		98
waist-hip ratio	EFO_0004343	1	13	13		97.8
waist circumference	EFO_0004342	1	10	10		95.9
BMI-adjusted waist circumference	EFO_0007789	1	7	7		92.2
BMI-adjusted hip circumference	EFO_0008039	2	9	10		85.3

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	15		98
waist-hip ratio	EFO_0004343	13		97.8
waist circumference	EFO_0004342	10		95.9
BMI-adjusted waist circumference	EFO_0007789	7		92.2
BMI-adjusted hip circumference	EFO_0008039	10		85.3

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
ATP-binding
Complete proteome
Lysosome
Membrane
Nucleotide-binding
Peptide transport
Polymorphism
Protein transport
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
allergic rhinitis
apolipoprotein A 1 measurement
atrial fibrillation
BMI-adjusted hip circumference
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body fat distribution
body mass index
Eczema
eosinophil percentage of leukocytes

MGI Phenotype Find Similar Targets

No Header	No Header
endocrine/exocrine gland phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ATP binding cassette subfamily B member 9	VGNC:4911	452335
Macaque	ATP binding cassette subfamily B member 9		707709
Mouse	ATP-binding cassette, sub-family B (MDR/TAP), member 9	MGI:1861729	56325
Rat	ATP binding cassette subfamily B member 9	RGD:620254	63886
Dog	ATP binding cassette subfamily B member 9 [Source:HGNC Symbol;Acc:HGNC:50]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ATP binding cassette subfamily B member 9
Macaque	ATP binding cassette subfamily B member 9
Mouse	ATP-binding cassette, sub-family B (MDR/TAP), member 9
Rat	ATP binding cassette subfamily B member 9
Dog	ATP binding cassette subfamily B member 9 [Source:HGNC Symbol;Acc:HGNC:50]

Publication Statistics

PubMed Score 51.21

PubMed score by year

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PubTator Score 26.08

PubTator score by year

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Related Publications

Text Mined References (34)

GeneRif Annotations (11)

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PMID	Year	Title