Tbio SSU72 RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Protein Summary

Description

Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.

Uniprot Accession IDs

• Q9NP77
• Q9BZS6
• Q9H933
• CTD phosphatase SSU72

Gene Name

• SSU72

Ensembl ID

• ENST00000291386
• ENSP00000291386
• ENSG00000160075
• ENST00000359060
• ENSP00000351955

Symbol

• HSPC182
• PNAS-120

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.96
histone modification site profile	0.86
transcription factor binding site profile	0.85
small molecule perturbation	0.75

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Rna Polymerase Ii Subunit A C-terminal Domain Phosphatase Ssu72

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Rna Polymerase Ii Subunit A C-terminal Domain Phosphatase Ssu72

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.25   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.25   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0