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Tbio
SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Protein Summary
Description
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291386
  • ENSP00000291386
  • ENSG00000160075
  • ENST00000359060
  • ENSP00000351955

Symbol
  • HSPC182
  • PNAS-120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.96
histone modification site profile
0.86
transcription factor binding site profile
0.85
small molecule perturbation
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.89   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.89   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
78.1
body height
2
2
2
73.4
serum albumin measurement
1
1
1
33.1
visceral adipose tissue measurement
1
1
1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
78.1
body height
2
73.4
serum albumin measurement
1
33.1
visceral adipose tissue measurement
1
11.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SSU72 homolog, RNA polymerase II CTD phosphatase
VGNC:8509
742879
Macaque
SSU72 homolog, RNA polymerase II CTD phosphatase
702348
Mouse
MGI:1916241
68991
Rat
RGD:1307854
298681
Dog
SSU72 homolog, RNA polymerase II CTD phosphatase
479567
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SSU72 homolog, RNA polymerase II CTD phosphatase
Macaque
SSU72 homolog, RNA polymerase II CTD phosphatase
Mouse
Rat
Dog
SSU72 homolog, RNA polymerase II CTD phosphatase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NP77-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Protein-Protein Interactions (181)
1 – 10 of 181
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.999996118
p_ni:  0.000003871
p_wrong:  1.1e-8
Data Source:  BioPlex
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.852014008
p_ni:  0.000021204
p_wrong:  0.147964788
Data Source:  BioPlex
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.996
Data Source:  STRINGDB
SYMPK
Tbio
Novelty:  0.01773552
Score:  0.996
Data Source:  STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.992
Data Source:  STRINGDB
WDR82
Tbio
Novelty:  0.04679153
Score:  0.992
Data Source:  STRINGDB
RPAP2
Tbio
Family:  Enzyme
Novelty:  0.03383659
Score:  0.989
Data Source:  STRINGDB
PCF11
Tbio
Novelty:  0.01882626
Score:  0.988
Data Source:  STRINGDB
POLR2B
Tbio
Family:  Enzyme
Novelty:  0.0012624
Score:  0.986
Data Source:  STRINGDB
CPSF2
Tbio
Novelty:  0.0510853
Score:  0.978
Data Source:  STRINGDB
Publication Statistics
PubMed Score  56.89

PubMed score by year
PubTator Score  13.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer