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Tbio
RAB18
Ras-related protein Rab-18

Protein Summary
Description
Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration. The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356940
  • ENSP00000349415
  • ENSG00000099246
  • ENST00000535776
  • ENSP00000439321
  • ENST00000621805
  • ENSP00000478479

Symbol
  • WARBM3
  • RAB18LI1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
interacting protein
0.86
transcription factor binding site profile
0.82
transcription factor perturbation
0.8
kinase perturbation
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.04   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.04   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB18, member RAS oncogene family
VGNC:12453
450372
Mouse
MGI:102790
19330
Rat
RGD:1308905
307039
Dog
RAB18, member RAS oncogene family
VGNC:45257
491408
Horse
RAB18, member RAS oncogene family
VGNC:22091
100055256
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB18, member RAS oncogene family
Mouse
Rat
Dog
RAB18, member RAS oncogene family
Horse
RAB18, member RAS oncogene family
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
COPI-independent Golgi-to-ER retrograde traffic (R-HSA-6811436)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-independent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Immune System
Innate Immune System
Intra-Golgi and retrograde Golgi-to-ER traffic
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (124)
1 – 10 of 124
FIS1
Tbio
Novelty: 0.0033607
p_int: 0.933932824
p_ni: 0.066067176
Data Source: BioPlex
GDI1
Tbio
Novelty: 0.01710945
p_int: 0.915670211
p_ni: 0.084329789
Score: 0.972
Data Source: BioPlex,Reactome,STRINGDB
LAMP2
Tbio
Novelty: 0.00168009
p_int: 0.897124818
p_ni: 0.102875182
Score: 0.268
Data Source: BioPlex,STRINGDB
RAB2B
Tdark
Family: Enzyme
Novelty: 0.18567584
p_int: 0.862621332
p_ni: 0.137378668
Score: 0.983
Data Source: BioPlex,STRINGDB
TACR3
Tchem
Family: GPCR
Novelty: 0.00351352
p_int: 0.854201122
p_ni: 0.145798874
p_wrong: 5e-9
Data Source: BioPlex
AGK
Tbio
Family: Enzyme
Novelty: 0.00919083
p_int: 0.778169983
p_ni: 0.221830017
Score: 0.191
Data Source: BioPlex,STRINGDB
RAB3GAP1
Tbio
Family: Enzyme
Novelty: 0.0286836
Score: 0.973
Data Source: Reactome,STRINGDB
RAB3GAP2
Tbio
Family: Enzyme
Novelty: 0.10321829
Score: 0.969
Data Source: Reactome,STRINGDB
RABGGTB
Tbio
Family: Enzyme
Novelty: 0.06786314
Score: 0.95
Data Source: STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
Score: 0.94
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  70.04

PubMed score by year
PubTator Score  32.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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