MLXIPL
Carbohydrate-responsive element-binding protein
Protein Summary
Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity). This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
- ENST00000313375
- ENSP00000320886
- ENSG00000009950
- ENST00000345114
- ENSP00000343767
- ENST00000354613
- ENSP00000346629
- ENST00000414749
- ENSP00000412330
- ENST00000429400
- ENSP00000406296
- BHLHD14
- MIO
- WBSCR14
- MIO
- MLX
- CHREBP
- MONDOB
- WBSCR14
- WS-bHLH
- bHLHd14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.97 | ||
trait | 0.75 | ||
disease | 0.66 | ||
gene perturbation | 0.63 | ||
molecular function | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 370.7 (req: < 5)
Gene RIFs: 85 (req: <= 3)
Antibodies: 315 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 370.7 (req: >= 5)
Gene RIFs: 85 (req: > 3)
Antibodies: 315 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0