Protein Summary
Involved in the mineralization and structural organization of enamel. This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. [provided by RefSeq, Aug 2011]
- ENST00000322937
- ENSP00000313809
- ENSG00000178522
- ENST00000449493
- ENSP00000391234
- AI1F
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.86 | ||
virus perturbation | 0.76 | ||
cell line | 0.56 | ||
tissue | 0.54 | ||
cellular component | 0.48 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 293.2 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 116 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 293.2 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 116 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0