Tbio ARFGAP3 ADP-ribosylation factor GTPase-activating protein 3

Protein Summary

Description

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• Q9NP61
• E9PB03
• Q9BSC6
• Q9H9J0
• Q9NT10
• Q9NUP5
• Q9Y4V3
• Q9Y4V4
• ARF GAP 3

Gene Name

• ARFGAP3

Ensembl ID

• ENST00000263245
• ENSP00000263245
• ENSG00000242247
• ENST00000437119
• ENSP00000388791

Symbol

• ARFGAP1
• ARFGAP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
kinase perturbation	0.81
virus perturbation	0.76
disease perturbation	0.74
protein complex	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.01   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 251   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.01   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0