SLC40A1
Solute carrier family 40 member 1
Protein Classes
Protein Summary
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
- ENST00000261024
- ENSP00000261024
- ENSG00000138449
- FPN1
- IREG1
- SLC11A3
- FPN1
- HFE4
- MTP1
- IREG1
- MST079
- MSTP079
- SLC11A3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 0.98 | ||
PubMedID | 0.97 | ||
transcription factor perturbation | 0.97 | ||
histone modification site profile | 0.79 | ||
biological process | 0.71 | ||
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 446.71 (req: < 5)
Gene RIFs: 116 (req: <= 3)
Antibodies: 326 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 446.71 (req: >= 5)
Gene RIFs: 116 (req: > 3)
Antibodies: 326 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 71
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (71)
1 – 10 of 71
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 74.5 | |||||
hematocrit | 2 | 2 | 2 | 62 | |||||
red blood cell distribution width | 2 | 1 | 2 | 49.3 | |||||
fibroblast growth factor 23 measurement | 1 | 1 | 1 | 13.5 | |||||
erythrocyte count | 1 | 1 | 1 | 11.2 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 2 | 74.5 | |||||
hematocrit | 2 | 62 | |||||
red blood cell distribution width | 2 | 49.3 | |||||
fibroblast growth factor 23 measurement | 1 | 13.5 | |||||
erythrocyte count | 1 | 11.2 | |||||
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 40 member 1 | VGNC:9060 | 459821 | |||||
Macaque | solute carrier family 40 member 1 | 713321 | ||||||
Mouse | MGI:1315204 | 53945 | ||||||
Rat | RGD:620180 | 170840 | ||||||
Dog | solute carrier family 40 member 1 | VGNC:46411 | 478837 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 40 member 1 | |||||
Macaque | solute carrier family 40 member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 40 member 1 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (15)
Reactome (11)
KEGG (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 11
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective CP causes aceruloplasminemia (ACERULOP) | ||||
Reactome | Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) | ||||
Reactome | Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective CP causes aceruloplasminemia (ACERULOP) | ||||
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) | ||||
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
Gene Ontology Terms (24)
Functions (5)
Components (9)
Processes (10)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (87)
1 – 10 of 87
HEPH
Novelty: 0.00609103
Score: 0.989
Data Source: Reactome,STRINGDB
CP
Novelty: 0.00103285
Score: 0.986
Data Source: Reactome,STRINGDB
HAMP
Novelty: 0.00035828
Score: 0.965
Data Source: STRINGDB
SLC11A2
Family: Transporter
Novelty: 0.00189409
Score: 0.913
Data Source: STRINGDB
TFR2
Family: Enzyme
Novelty: 0.00480264
Score: 0.874
Data Source: STRINGDB
HJV
Novelty: 0.00495995
Score: 0.847
Data Source: STRINGDB
CYBRD1
Family: Enzyme
Novelty: 0.01128708
Score: 0.842
Data Source: STRINGDB
HFE
Novelty: 0.00042077
Score: 0.84
Data Source: STRINGDB
SLC39A1
Family: Transporter
Novelty: 0.00678191
Score: 0.814
Data Source: STRINGDB
TFRC
Novelty: 0.00025984
Score: 0.799
Data Source: STRINGDB
Publication Statistics
PubMed Score 446.71
PubMed score by year
PubTator Score 219.96
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword
GWAS Trait