SLC40A1
Solute carrier family 40 member 1
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
small molecule perturbation | 0.98 | ||
PubMedID | 0.97 | ||
transcription factor perturbation | 0.97 | ||
histone modification site profile | 0.79 | ||
biological process | 0.71 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Defective CP causes aceruloplasminemia (ACERULOP) | ||||
Reactome | Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) | ||||
Reactome | Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Defective CP causes aceruloplasminemia (ACERULOP) | ||||
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) | ||||
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
ferritin measurement | 2 | 2 | 2 | 84.2 | |||||
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 74.1 | |||||
hematocrit | 2 | 2 | 2 | 61.8 | |||||
liver iron measurement | 1 | 2 | 2 | 54.3 | |||||
red blood cell distribution width | 2 | 1 | 2 | 48.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
ferritin measurement | 2 | 84.2 | |||||
mean corpuscular hemoglobin concentration | 2 | 74.1 | |||||
hematocrit | 2 | 61.8 | |||||
liver iron measurement | 2 | 54.3 | |||||
red blood cell distribution width | 2 | 48.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 40 member 1 | VGNC:9060 | 459821 | |||||
Macaque | solute carrier family 40 member 1 | 713321 | ||||||
Mouse | MGI:1315204 | 53945 | ||||||
Rat | RGD:620180 | 170840 | ||||||
Dog | solute carrier family 40 member 1 | VGNC:46411 | 478837 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | solute carrier family 40 member 1 | |||||
Macaque | solute carrier family 40 member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 40 member 1 | |||||
PMID | Year | Title |
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