SLC40A1
Solute carrier family 40 member 1
Protein Summary
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
- ENST00000261024
- ENSP00000261024
- ENSG00000138449
- FPN1
- IREG1
- SLC11A3
- FPN1
- HFE4
- MTP1
- IREG1
- MST079
- MSTP079
- SLC11A3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 0.98 | ||
PubMedID | 0.97 | ||
transcription factor perturbation | 0.97 | ||
histone modification site profile | 0.79 | ||
biological process | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 465.06 (req: < 5)
Gene RIFs: 116 (req: <= 3)
Antibodies: 326 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 465.06 (req: >= 5)
Gene RIFs: 116 (req: > 3)
Antibodies: 326 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 182
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (182)
Protein-Protein Interactions (87)
Nearest Tclin Targets
Pathways (15)
Reactome (11)
KEGG (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective CP causes aceruloplasminemia (ACERULOP) | ||||
Reactome | Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) | ||||
Reactome | Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective CP causes aceruloplasminemia (ACERULOP) | ||||
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) | ||||
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (5)
Components (9)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
ferritin measurement | 2 | 2 | 2 | 84.2 | |||||
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 74.1 | |||||
hematocrit | 2 | 2 | 2 | 61.8 | |||||
liver iron measurement | 1 | 2 | 2 | 54.3 | |||||
red blood cell distribution width | 2 | 1 | 2 | 48.5 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
ferritin measurement | 2 | 84.2 | |||||
mean corpuscular hemoglobin concentration | 2 | 74.1 | |||||
hematocrit | 2 | 61.8 | |||||
liver iron measurement | 2 | 54.3 | |||||
red blood cell distribution width | 2 | 48.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 40 member 1 | VGNC:9060 | 459821 | |||||
Macaque | solute carrier family 40 member 1 | 713321 | ||||||
Mouse | MGI:1315204 | 53945 | ||||||
Rat | RGD:620180 | 170840 | ||||||
Dog | solute carrier family 40 member 1 | VGNC:46411 | 478837 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 40 member 1 | |||||
Macaque | solute carrier family 40 member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 40 member 1 | |||||
Publication Statistics
PubMed Score 465.06
PubMed score by year
PubTator Score 219.96
PubTator score by year
Related Publications
Text Mined References (152)
GeneRif Annotations (116)
Items per page:
0 of 0
PMID | Year | Title |
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