Tbio BPIFA1 BPI fold-containing family A member 1

Protein Summary

Description

Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression. This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]

Uniprot Accession IDs

• Q9NP55
• A6XMV5
• A8K9R3
• E1P5M9
• Q9NZT0

Gene Name

• BPIFA1

Ensembl ID

• ENST00000354297
• ENSP00000346251
• ENSG00000198183
• ENST00000375413
• ENSP00000364562
• ENST00000375422
• ENSP00000364571
• ENST00000618484
• ENSP00000482297

Symbol

• LUNX
• NASG
• PLUNC
• SPLUNC1
• SPURT
• LUNX
• NASG
• PLUNC
• SPURT
• SPLUNC1
• bA49G10.5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.62
cell type or tissue	0.61
disease	0.51
cell line	0.43
chemical	0.43

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.46   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.46   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0