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Tbio
BPIFA1
BPI fold-containing family A member 1

Protein Summary
Description
Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression. This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the uppe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354297
  • ENSP00000346251
  • ENSG00000198183
  • ENST00000375413
  • ENSP00000364562
  • ENST00000375422
  • ENSP00000364571
  • ENST00000618484
  • ENSP00000482297

Symbol
  • LUNX
  • NASG
  • PLUNC
  • SPLUNC1
  • SPURT
  • LUNX
  • NASG
  • PLUNC
  • SPURT
  • SPLUNC1
  • bA49G10.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.62
cell type or tissue
0.61
disease
0.51
cell line
0.43
chemical
0.43


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.24   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.24   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
87.3
BMI-adjusted hip circumference
2
2
2
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
87.3
BMI-adjusted hip circumference
2
63.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BPI fold containing family A member 1
VGNC:6054
458177
Macaque
BPI fold containing family A member 1
714509
Mouse
MGI:1338036
18843
Rat
RGD:619818
246238
Dog
BPI fold containing family A member 1
VGNC:38504
609982
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BPI fold containing family A member 1
Macaque
BPI fold containing family A member 1
Mouse
Rat
Dog
BPI fold containing family A member 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NP55-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (55)
1 – 10 of 55
BPIFB3
Tdark
Novelty:  0.2161337
p_int:  1
Score:  0.858
Data Source:  BioPlex,STRINGDB
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999998289
p_ni:  0.000001702
p_wrong:  8e-9
Data Source:  BioPlex
TMEM237
Tdark
Novelty:  0.27005874
p_int:  0.999987032
p_ni:  0.00001237
p_wrong:  5.98e-7
Score:  0.28
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999982239
p_ni:  0.000011377
p_wrong:  0.000006384
Data Source:  BioPlex
ICE2
Tbio
Novelty:  0.03407933
p_int:  0.999978199
p_ni:  0.000014486
p_wrong:  0.000007315
Score:  0.209
Data Source:  BioPlex,STRINGDB
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
p_int:  0.999865191
p_ni:  0.000028069
p_wrong:  0.00010674
Score:  0.169
Data Source:  BioPlex,STRINGDB
HBM
Tdark
Novelty:  0.02658671
p_int:  0.999766769
p_ni:  0.000127855
p_wrong:  0.000105376
Score:  0.163
Data Source:  BioPlex,STRINGDB
COX7B2
Tdark
Family:  Enzyme
Novelty:  0.92736353
Score:  0.8
Data Source:  STRINGDB
BPI
Tbio
Novelty:  0.00229665
Score:  0.784
Data Source:  STRINGDB
BPIFB2
Tbio
Novelty:  0.2051039
Score:  0.736
Data Source:  STRINGDB
Publication Statistics
PubMed Score  209.24

PubMed score by year
PubTator Score  119.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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