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Tbio
SH2D2A
SH2 domain-containing protein 2A

Protein Summary
Description
Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368198
  • ENSP00000357181
  • ENSG00000027869
  • ENST00000368199
  • ENSP00000357182
  • ENST00000392306
  • ENSP00000376123

Symbol
  • SCAP
  • TSAD
  • VRAP
  • SCAP
  • TSAD
  • VRAP
  • F2771
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
gene perturbation
0.64
tissue sample
0.54
hub protein
0.53
tissue
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.19   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 295   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.19   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
47.9
autoimmune thyroid disease
1
1
0
1.1
46.1
platelet crit
1
1
1
40.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
47.9
autoimmune thyroid disease
0
1.1
46.1
platelet crit
1
40.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing 2A
VGNC:1546
457406
Macaque
SH2 domain containing 2A
718686
Mouse
MGI:1351596
27371
Rat
RGD:1303076
310688
Dog
SH2 domain containing 2A
VGNC:46111
100687395
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing 2A
Macaque
SH2 domain containing 2A
Mouse
Rat
Dog
SH2 domain containing 2A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NP31-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signaling by VEGF
Reactome
VEGFA-VEGFR2 Pathway
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Receptor Tyrosine Kinases
Signaling by VEGF
VEGFA-VEGFR2 Pathway
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (49)
1 – 10 of 49
KDM1B
Tbio
Family: Epigenetic
Novelty: 0.02174039
p_int: 0.998638465
p_ni: 0.001358001
p_wrong: 0.000003534
Score: 0.519
Data Source: BioPlex,STRINGDB
PEAK1
Tbio
Family: Kinase
Novelty: 0.02919858
p_int: 0.878620143
p_ni: 0.121379857
Score: 0.534
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.98
Data Source: Reactome,STRINGDB
KDR
Tclin
Family: Kinase
Novelty: 0.00016219
Score: 0.969
Data Source: Reactome,STRINGDB
MAP3K2
Tchem
Family: Kinase
Novelty: 0.01201472
Score: 0.951
Data Source: STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
Score: 0.95
Data Source: Reactome,STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.932
Data Source: Reactome,STRINGDB
VAV1
Tchem
Novelty: 0.00180518
Score: 0.918
Data Source: STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.904
Data Source: STRINGDB
AXL
Tchem
Family: Kinase
Novelty: 0.00132459
Score: 0.903
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  47.19

PubMed score by year
PubTator Score  35.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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