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Tchem
CD209
CD209 antigen

Protein Summary
Description
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2. (Microbial infection) Acts as an attachment receptor for Ebolavirus. (Microbial infection) Acts as an atta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000204801
  • ENSP00000204801
  • ENSG00000090659
  • ENST00000315591
  • ENSP00000315407
  • ENST00000315599
  • ENSP00000315477
  • ENST00000354397
  • ENSP00000346373
  • ENST00000394161
  • ENSP00000377716
  • ENST00000601256
  • ENSP00000470658
  • ENST00000601951
  • ENSP00000468827
  • ENST00000602261
  • ENSP00000471137

Symbol
  • CLEC4L
  • CDSIGN
  • CLEC4L
  • DC-SIGN
  • DC-SIGN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
cellular component
0.82
cell type or tissue
0.77
phenotype
0.67
gene perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1095.03   (req: < 5)
Gene RIFs: 270   (req: <= 3)
Antibodies: 1369   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1095.03   (req: >= 5)
Gene RIFs: 270   (req: > 3)
Antibodies: 1369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0