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Tbio
TUFT1
Tuftelin

Protein Classes
Protein Summary
Description
Involved in the mineralization and structural organization of enamel. Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368848
  • ENSP00000357841
  • ENSG00000143367
  • ENST00000368849
  • ENSP00000357842
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
kinase perturbation
0.91
small molecule perturbation
0.88
transcription factor perturbation
0.8
PubMedID
0.78


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.85   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.85   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tuftelin 1
VGNC:1712
747604
Macaque
tuftelin 1
716814
Mouse
MGI:109572
22156
Rat
RGD:1310373
365864
Horse
tuftelin 1
VGNC:24666
100059946
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tuftelin 1
Macaque
tuftelin 1
Mouse
Rat
Horse
tuftelin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NNX1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (29)
1 – 10 of 29
RABGAP1
Tbio
Family: Enzyme
Novelty: 0.14270101
p_int: 0.999999539
p_ni: 4.61e-7
Score: 0.604
Data Source: BioPlex,STRINGDB
EXOC1
Tbio
Novelty: 0.01073858
p_int: 0.999998786
p_ni: 0.000001214
Data Source: BioPlex
CYTH4
Tbio
Novelty: 0.05783135
p_int: 0.99999705
p_ni: 0.00000295
Data Source: BioPlex
DMAP1
Tbio
Family: Enzyme
Novelty: 0.03152166
p_int: 0.999984196
p_ni: 0.000014039
p_wrong: 0.000001765
Data Source: BioPlex
ATF1
Tchem
Family: TF
Novelty: 0.01450941
p_int: 0.999668864
p_ni: 0.000118756
p_wrong: 0.00021238
Score: 0.303
Data Source: BioPlex,STRINGDB
ZYX
Tbio
Novelty: 0.00375452
p_int: 0.996810504
p_ni: 0.003189476
p_wrong: 2e-8
Score: 0.5
Data Source: BioPlex,STRINGDB
SMC6
Tbio
Novelty: 0.02450073
p_int: 0.993068524
p_ni: 0.006931476
Score: 0.729
Data Source: BioPlex,STRINGDB
RABGAP1L
Tbio
Family: Enzyme
Novelty: 0.2377644
p_int: 0.992576884
p_ni: 0.007423008
p_wrong: 1.09e-7
Score: 0.6
Data Source: BioPlex,STRINGDB
CREB1
Tbio
Family: TF
Novelty: 0.00018059
p_int: 0.987745886
p_ni: 0.012254114
Score: 0.198
Data Source: BioPlex,STRINGDB
TFIP11
Tbio
Novelty: 0.01546496
Score: 0.876
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.85

PubMed score by year
PubTator Score  31.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer