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Tbio
Q9HDB5
Neurexin-3-beta

Protein Summary
Description
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity). This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281127
  • ENSP00000281127
  • ENSG00000021645
  • ENST00000428277
  • ENSP00000394426
  • ENST00000557594
  • ENSP00000451672

Symbol
  • KIAA0743
  • C14orf60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.92
transcription factor perturbation
0.84
cell type or tissue
0.83
transcription factor
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.49   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.49   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (179)
HADHA
Tbio
Novelty:  0.00385746
p_int:  0.999999947
p_ni:  5.3e-8
Data Source:  BioPlex
GPR183
Tchem
Family:  GPCR
Novelty:  0.02005679
p_int:  0.999999686
p_ni:  3.11e-7
p_wrong:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.999999415
p_ni:  5.85e-7
Score:  0.193
Data Source:  BioPlex,STRINGDB
PIP5K1A
Tbio
Family:  Kinase
Novelty:  0.05039085
p_int:  0.999995463
p_ni:  0.000004508
p_wrong:  3e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.999995282
p_ni:  0.000004717
Score:  0.229
Data Source:  BioPlex,STRINGDB
CBLN4
Tbio
Novelty:  0.11296355
p_int:  0.999972805
p_ni:  0.000027185
p_wrong:  9e-9
Score:  0.593
Data Source:  BioPlex,STRINGDB
FAM19A1
Tbio
Novelty:  0.27533335
p_int:  0.999870207
p_ni:  0.000120389
p_wrong:  0.000009404
Score:  0.343
Data Source:  BioPlex,STRINGDB
LRRTM4
Tbio
Novelty:  0.07741851
p_int:  0.999417674
p_ni:  0.000497671
p_wrong:  0.000084655
Score:  0.948
Data Source:  BioPlex,STRINGDB
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.939905554
p_ni:  0.00179219
p_wrong:  0.058302256
Data Source:  BioPlex
NLGN1
Tbio
Family:  Enzyme
Novelty:  0.0097512
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
12
4
44
96
body mass index
12
4
44
96
5
5
6
1.1
93.6
5
5
6
1.1
93.6
anthropometric measurement
1
2
0
1.1
81
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
44
96
body mass index
44
96
6
1.1
93.6
6
1.1
93.6
anthropometric measurement
0
1.1
81
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neurexin 3
678699
Mouse
MGI:1096389
18191
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neurexin 3
Mouse
Publication Statistics
PubMed Score 137.49
PubMed score by year
PubTator Score 36.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title