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Tbio
RETN
Resistin

Protein Summary
Description
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728). This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221515
  • ENSP00000221515
  • ENSG00000104918
  • ENST00000381324
  • ENSP00000370725
  • ENST00000629642
  • ENSP00000485998

Symbol
  • FIZZ3
  • HXCP1
  • RSTN
  • ADSF
  • RSTN
  • XCP1
  • FIZZ3
  • RETN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
gene perturbation
0.99
cell type or tissue
0.77
biological process
0.67
chemical
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1773.01   (req: < 5)
Gene RIFs: 489   (req: <= 3)
Antibodies: 814   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1773.01   (req: >= 5)
Gene RIFs: 489   (req: > 3)
Antibodies: 814   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
3
4
93.1
resistin measurement
1
2
0
6.2
91.1
leukocyte count
1
3
3
89.1
aspartate aminotransferase measurement
1
1
0
9.5
73.9
von Willebrand factor measurement
1
1
2
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
93.1
resistin measurement
0
6.2
91.1
leukocyte count
3
89.1
aspartate aminotransferase measurement
0
9.5
73.9
von Willebrand factor measurement
2
65.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
resistin
VGNC:12073
742100
Mouse
MGI:1888506
57264
Rat
RGD:628781
246250
Dog
resistin
VGNC:45482
611540
Cow
resistin
VGNC:33877
369020
Species
Name
OMA
EggNOG
Inparanoid
Chimp
resistin
Mouse
Rat
Dog
resistin
Cow
resistin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9HD89-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
FOXO-mediated transcription (R-HSA-9614085)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (274)
1 – 10 of 274
GLI4
Tbio
Family:  TF
Novelty:  0.15339473
p_int:  0.999994028
p_ni:  7.07e-7
p_wrong:  0.000005265
Score:  0.359
Data Source:  BioPlex,STRINGDB
SQSTM1
Tbio
Novelty:  0.00100555
p_int:  0.997093079
p_ni:  0.002906921
Score:  0.187
Data Source:  BioPlex,STRINGDB
APEX2
Tbio
Family:  Enzyme
Novelty:  0.04076395
p_int:  0.997045071
p_ni:  0.002953497
p_wrong:  0.000001432
Score:  0.209
Data Source:  BioPlex,STRINGDB
ZNF664
Tdark
Family:  TF
Novelty:  0.25879878
p_int:  0.981509585
p_ni:  0.000142567
p_wrong:  0.018347848
Score:  0.313
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.926814004
p_ni:  0.073185996
Score:  0.244
Data Source:  BioPlex,STRINGDB
MPO
Tchem
Family:  Enzyme
Novelty:  0.00020698
Score:  0.957
Data Source:  STRINGDB
ARG1
Tchem
Family:  Enzyme
Novelty:  0.00063728
Score:  0.956
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.955
Data Source:  STRINGDB
LCN2
Tbio
Family:  Enzyme
Novelty:  0.00034678
Score:  0.95
Data Source:  STRINGDB
ELANE
Tclin
Family:  Enzyme
Novelty:  0.00026112
Score:  0.944
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1773.01

PubMed score by year
PubTator Score  603.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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