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Tbio
MYO10
Unconventional myosin-X

Protein Classes
Protein Summary
Description
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000507288
  • ENSP00000426664
  • ENSG00000145555
  • ENST00000513610
  • ENSP00000421280

Symbol
  • KIAA0799
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
trait
0.99
transcription factor perturbation
0.99
kinase perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.3   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.3   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
1
1
1
34.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
1
34.8
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
Gene Ontology Terms (24)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (79)
1 – 10 of 79
JPH4
Tbio
Novelty: 0.07699598
p_int: 0.999999697
p_ni: 3.02e-7
Score: 0.248
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999997884
p_ni: 0.000002104
p_wrong: 1.1e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
DCC
Tbio
Novelty: 0.01273911
Score: 0.984
Data Source: Reactome,STRINGDB
NEO1
Tbio
Novelty: 0.00625858
Score: 0.945
Data Source: Reactome,STRINGDB
ACTG1
Tbio
Novelty: 0.00086444
Score: 0.926
Data Source: Reactome,STRINGDB
NTN1
Tbio
Novelty: 0.00183678
Score: 0.926
Data Source: STRINGDB
ARPC3
Tbio
Novelty: 0.02951522
Score: 0.926
Data Source: STRINGDB
ARPC5
Tbio
Novelty: 0.03434234
Score: 0.924
Data Source: STRINGDB
ACTR2
Tbio
Novelty: 0.00731489
Score: 0.923
Data Source: STRINGDB
ACTB
Tbio
Novelty: 0.00006048
Score: 0.923
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  56.30

PubMed score by year
PubTator Score  49.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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