Tbio XAGE1A X antigen family member 1

Protein Summary

Description

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q9HD64
• A6NJ94
• Q5JPN8
• Q5JPP0
• Q5JPP3
• Q8WWG5
• Q8WWG6
• Q969J6
• XAGE-1

Gene Name

• XAGE1A

Ensembl ID

• ENST00000375600
• ENSP00000364750
• ENSG00000204379
• ENST00000375602
• ENSP00000364752
• ENST00000375613
• ENSP00000364763
• ENSG00000204382
• ENST00000375616
• ENSP00000364766
• ENST00000518075
• ENSP00000430130

Symbol

• GAGED2
• XAGE1
• CTP9
• XAGE1
• CT12.1
• GAGED2
• XAGE-1
• XAGE1C
• XAGE1D
• XAGE1E
• CT12.1C
• CT12.1D
• CT12.1E
• CT12.1b

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.65   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 74   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.65   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0