Tbio SEPSECS O-phosphoseryl-tRNA(Sec) selenium transferase

Protein Summary

Description

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q9HD40
• A8K8W1
• Q0D2P3
• Q17RT1
• Q9NXZ5
• Q9UGM9
• Q9Y353

Gene Name

• SEPSECS

Ensembl ID

• ENST00000382103
• ENSP00000371535
• ENSG00000109618
• ENST00000514585
• ENSP00000421880

Symbol

• TRNP48
• LP
• SLA
• PCH2D
• SLA/LP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
transcription factor binding site profile	0.78
protein domain	0.73
microRNA	0.64
tissue	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.39   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.39   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0